To facilitate the study of the mechanisms of breast cancer metastasis we have previously characterized a pair of breast tumor cell lines that originate from the same breast tumor cell line MDA-MB-435, but which have diametrically opposite metastatic capabilities. These cell lines constitute a stable and accessible experimental system for the identification of metastasis-related genes and for th...

Using Reclaimed Asphalt Pavement (RAP) in asphalt mixes has become a common practice in many countries as experience indicated that the recycling of asphalt pavements is very advantageous from different perspectives. Some of the advantages of utilizing RAP include conservation of asphalt and aggregate resources, conservation of energy, and reduction in life-cycle cost. In this study, the suitab...

The Rap protein of phage lambda is an endonuclease that nicks branched DNA structures. It has been proposed that Rap can nick D-loops formed during phage recombination to generate splice products without the need for the formation of a 4-strand (Holliday) junction. The structure specificity of Rap was investigated using a variety of branched DNA molecules made by annealing partially complementa...

Hemodilution is one of the sequelae of cardiopulmonary bypass (CPB). Autologous blood priming (retrograde autologous priming [RAP]/venous antegrade priming [VAP]) and acute normovolemic hemodilution (ANH) may be effective techniques to minimize hemodilution. The primary objective of this study is to investigate the impact of RAP/VAP combined with ANH on changes in cerebral saturations. A retros...

We show that cell lines derived from childhood alveolar rhabdomyosarcoma (RMS) are very sensitive to the growth-inhibitory effects of the immunosuppressive agent rapamycin (RAP), compared to other human cell lines (50% inhibitory concentration range of 0.1-8 ng/mi, compared to 1280 to >10,000 ng/ml). Our data suggest that the sensitivity of RMS lines is due to RAP inhibition of insulin-like gro...

We show that cell lines derived from childhood alveolar rhabdomyosarcoma (RMS) are very sensitive to the growth-inhibitory effects of the immunosuppressive agent rapamycin (RAP), compared to other human cell lines (50% inhibitory concentration range of 0.1-8 ng/mi, compared to 1280 to >10,000 ng/ml). Our data suggest that the sensitivity of RMS lines is due to RAP inhibition of insulin-like gro...

Constituído de letra e canção, o rap é um gênero musical afro-diaspórico que mobiliza engaja diversos sujeitos por meio da cultura periférica. A “nova condição do rap” enquanto uma categoria análise nos ajuda a compreender novas características deste musical, possibilitou refletir sobre possível religiosa” rap. Dessa forma, este artigo tem como objetivo 1) os “modos mítico-poéticos” brasileiro ...

Rap is a member of the Ras family of small GTPases. Mammalian Rap proteins regulate many biological processes including cell and matrix adhesion, migration, proliferation, cytoskeletal dynamics, cell polarity and secretion. Rap1 is activated by TSH and cAMP in thyroid cells independently of PKA. TSH regulates differentiated gene expression and proliferation. Many of these effects are mediated t...

ii To my family, friends and professors who helped me throughout this experience iii ACKNOWLEDGEMENTS This research project was made possible with the help of many supporting people throughout the process. I wish to express my gratitude firstly to my supervising professor, Dr. Hosin " David " Lee for the support and advice needed to start and finish this project. I would also like to thank the ...

OBJECTIVES To correlate clinical and histopathologic features of an eye with retinal angiomatous proliferation (RAP) secondary to age-related macular degeneration and to investigate the expression of von Willebrand factor (VWF) and vascular endothelial growth factor (VEGF) in this condition. METHODS Histopathologic features from serial sections through the globe of an 87-year-old woman with R...