We present a force-displacement contact model for the compressive loading of elastoplastic spheres. This model builds from the well known Hertz contact law for elastic, quasistatic compression to incorporate a material's strain-rate-dependent plasticity in order to describe collisions between particles. In the quasistatic regime, finite-element analysis is used to derive an empirical function o...

Abstract Size effects in metal plasticity are widely accepted, and different theoretical approaches to handle the phenomenon developing literature. The present work considers Fleck Willis (2009b) framework, creates a new gradient enhanced rate-independent crystal FE-implementation. study both energetic dissipative hardening strengthening, adopts general form of effective slip rate. Monotonic cy...

The properties and behaviour of an  colony Ti-6242 alloy have been investigated at 20C utilising coupled micro-pillar stress relaxation tests and computational crystal plasticity. The -phase slip strength and intrinsic slip system strain rate sensitivity have been determined, and the -phase shown to have stronger rate sensitivity than that for the  phase. Close agreement of experimental o...

Experience-dependent maturation of neocortical circuits is required for normal sensory and cognitive abilities, which are distorted in neurodevelopmental disorders. We tested whether experience-dependent neocortical modifications require Ube3a, an E3 ubiquitin ligase whose dysregulation has been implicated in autism and Angelman syndrome. Using visual cortex as a model, we found that experience...

Experience-dependent synaptic plasticity refines brain circuits during development. To identify novel protein synthesis-dependent mechanisms contributing to experience-dependent plasticity, we conducted a quantitative proteomic screen of the nascent proteome in response to visual experience in Xenopus optic tectum using bio-orthogonal metabolic labeling (BONCAT). We identified 83 differentially...

Long-term potentiation (LTP) is a form of activity dependent plasticity that induced by high-frequency stimulation or theta burst stimulation and results in synaptic transmission. Several Studies have been shown that LTP is one of the most important processes in the CNS that plays an important role in learning and memory formation. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a major...

Abstract The texture profile analysis test is an imitative to determine properties of food, which quantify the consumer’s perception eating food. instrumental parameters obtained from this depend on specimen size and nonstandardized conditions. To overcome problem, are here related intrinsic mechanical properties, independent Two types materials used investigate effect viscoelasticity, plastici...