PurposeThe in vitro clonogenic assay (IVCA) is the mainstay of quantitative radiobiology. Here, we investigate benefit a time-resolved IVCA version (trIVCA) to improve quantification survival and relative biological effectiveness (RBE) by analyzing cell colony growth behavior.Materials & MethodsIn IVCA, clonogenicity classification colonies performed based on fixed size threshold after incubati...

According to track theory, the relative biological effectiveness (RBE) of high linear energy transfer (LET) radiations varies with cellular radiosensitivity parameters and the radiation environment. Of special interest is that the RBE varies as the dose of high-LET radiation to the power (1/m - 1) where m is the "target number" parameter, which varies from 2-4 in different cell lines. This appl...

The Local Effect Model (LEM) represents an integral part of the heavy ion treatment planning software TRiP98 to calculate the biologically equivalent dose. Recently, the incorporation of cluster effects of single strand breaks at large local doses around the center of ion tracks was shown to be of particular importance for the prediction of the relative biological effectiveness (RBE) of the ini...

Although previous studies have explored how satisfied people are with their travel, the link built environment and available travel options is unclear. This research investigates whether influence commute time satisfaction relates to environment. First, profiles among commuters in terms of (CTS) residential (RBE) were identified by performing a cluster analysis using large European sample Union...

BACKGROUND Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the Spread-Out Bragg Peak (SOBP). Towards this end, we investigated the differences in the biological effect of a high-energy proton beam on the target cells placed at different pos...

To better assess the potential biological consequences of diagnostic x-rays and selected gamma-emitting radioisotopes used in brachytherapy, we used the PENELOPE Monte Carlo radiation transport code to estimate the spectrum of initial electrons produced by photons in single cells and in an irradiation geometry similar to those used in cell culture experiments. We then combined estimates of the ...

BACKGROUND Carbon-ion radiotherapy (CIRT) is a promising treatment for locally advanced non-small-cell lung cancer, especially for patients with inoperable lung cancer. Although the incidence of CIRT-induced radiation pneumonitis (RP) ≥ grade 2 ranges from 2.5 to 9.9%, the association between CIRT-induced RP and dosimetric parameters is not clear. Herein, we identified prognostic factors associ...

BACKGROUND The purpose of the present study was to evaluate retrospectively the efficacy and safety of proton beam therapy for elderly patients (≥80 years of age) with non-small cell lung cancer. METHODS Patients diagnosed with T1-4 N0 M0 non-small cell lung cancer and treated with proton beam therapy between January 2009 and 2015 were recruited from our database retrospectively. Toxicity was...

OBJECTIVES Our objective was to report initial results of a dose escalation trial of single-fraction carbon ion radiotherapy for peripheral stage I NSCLC. METHODS Between April 2003 and February 2012, a total of 218 patients were treated. The total dose was raised from 28 to 50 Gy (relative biological effectiveness [RBE]). There were 157 male and 61 female patients, with a median age of 75 ye...