Two classes of molecules inhibit the catalytic subunit (C) of the cyclic AMP-dependent protein kinase (cAPK), the heat-stable protein kinase inhibitors (PKIs) and the regulatory (R) subunits. Basic sites on C, previously identified as important for R/C interaction in yeast TPKI and corresponding to Lys213, Lys217, and Lys189 in murine Ca, were replaced with either Ala or Thr and characterized f...

For the safety of prestressed structures, prestress loss is a critical issue that will increase with structural damage, so it is necessary to investigate prestress loss of prestressed structures under different damage scenarios. Unfortunately, to date, no qualified techniques are available due to difficulty for sensors to survive in harsh construction environments of long service life and large...

Before implementing a bridge monitoring strategy, manager would like to know the return on investment. Moreover, in order spend available budget as efficiently possible, strategy should be optimized, i.e., type of measurements but also time and locations at which these are performed. For this purpose, Value Information (VoI) can used. The VoI represents an estimate benefit that gained from befo...

In this article, a study of the snapback behavior reverse conducting IGBTs (RC-IGBTs) by means 2-D TCAD simulations is carried out. Half-cell models 1200-V RC-IGBT structures with different voltage levels were generated varying peak doping concentration punch-through N-buffer region. First observations show that could be an issue for low current switching commutations paralleled RC-IGBTs operat...

We study a class of double coset spaces RA\G1 × G2/RC , where G1 and G2 are connected reductive algebraic groups, and RA and RC are certain spherical subgroups of G1×G2 obtained by “identifying” Levi factors of parabolic subgroups in G1 and G2. Such double cosets naturally appear in the symplectic leaf decompositions of Poisson homogeneous spaces of complex reductive groups with the Belavin–Dri...