[reaction: see text] A highly selective catalytic reductive isomerization reaction is described. The extremely mild and neutral reaction conditions (10% Pd/C, H2, and MeOH at 0 degrees C) tolerate a wide range of functional groups and generally result in excellent yields. Mechanistic studies suggest that this reaction does not proceed via a stepwise reduction/elimination sequence or a pi-allylp...

Computational insight into the multi-step reaction cycle of aromatic amine dehydrogenase is presented, identifying the energy landscape and pathway for multiple proton transfers. This atomistic picture of the reaction sequence--including short-lived reaction intermediates and a stepwise reaction mechanism--bridges the gap between a small number of crystallographic snapshots.

We report a Lewis acid catalyzed reaction sequence involving a 1,2-shift and subsequent C–H insertion that gives monocyclic and fused bicyclic cyclopentenone products. This reaction sequence, which is initiated by treating b-hydroxy-a-diazo ketones with a Lewis acid, proceeds through vinyl cation intermediates that insert at non-activated gamma C–H bonds. This reaction represents an alternative...

Previous studies (1) have indicated that a-GP’ is an important intermediate in the incorporation of radioactive inorganic phosphate into a phosphatide fraction of rat liver. The dependence of the incorporation on oxidative phosphorylation and the marked stimulation by the addition of free glycerol suggested that the first stages in this reaction sequence were the conversion of radioactive ortho...