In reactive and postinfectious arthritis the joints are generally sterile but the presence of bacterial antigens and nucleic acids has been reported. To investigate whether organisms traffic to affected joints in these conditions, we performed reverse transcription PCR using universal primers to amplify any bacterial 16S rRNA sequences present in synovial fluid. Bacterial sequences were detecte...

Forty-two male patients with reactive spondyloarthropathies in a Dutch military hospital are described with mean age of onset 21.9 years. Peripheral arthritis or sacroiliitis was present in all, eye symptoms in 21 (50%), and genitourinary disease in 15 (35.7%). Evidence of antecedent sexually acquired or enterocolitic infection was found only in three (7.2%). HLA-B27 antigen was detected in 34 ...

Background Clostridium difficile infection (CDI) is a common cause of antibiotic-associated diarrhea and can be difficult to cure. Most patients with CDI present only colonopathy and in fewer cases extra intestinal features were described such as reactive arthritis (ReA). We present a series of cases with CDI-associated reactive arthritis (CDI-AReA), admitted between 2011-2014 in the National I...

The survival and fate of Salmonella enterica serotype Enteritidis in Henle-407 human intestinal epithelial cells was investigated during prolonged incubation to evaluate the persistence of causative microbes and the relationship to patients developing reactive arthritis. Most of the bacteria were killed and degraded quite soon after infection of the cells, but there were still live bacteria ins...

Reactive arthritis is a rare complication of Clostridium difficile enterocolitis, especially in children. We review the 6 pediatric cases published in the English and non-English literature and discuss their clinical presentation, outcome, treatment, and pathophysiology. We also report the seventh case of Clostridium difficile reactive arthritis in a 6-year-old boy who was treated with amoxicil...

Background: Reactive arthritis is a form of spondyloarthritis with aseptic joint involvement occurring after gastrointestinal or urogenital infection. Most commonly associated Chlamydia trachomatis , Salmonella, Shigella, Campylobacter and Yersinia. Syphilis an infection caused by the spirochete Treponema pallidum not usually reactive arthritis. great imitator other diseases due to its broad pr...

Patients who develop reactive arthritis after yersinia enteritis are characterised by high and persisting IgA-anti-yersinia antibodies. We have further analysed the humoral immune response to yersinia in this condition. Total concentrations of IgM, IgG, IgA, and secretory IgA in the serum and specific anti-yersinia antibodies belonging to IgA1, IgA2, or secretory IgA were compared in patients w...

Objectives. Chronic periaortitis (CP) is a rare disease with a potentially immune-mediated pathogenesis. The study aims to report the frequency and the clinical characteristics of peripheral inflammatory arthritis in a cohort of CP patients, and to review the literature regarding the association between arthritis and CP. Methods. Forty-nine consecutive CP patients were seen at our department be...

Reactive arthritis is usually a self-limiting polyarthritis which develops after certain gastrointestinal or urogenital infections. Microbial antigens found in the inflamed joints are thought to play a key role in the development of this disease. It is not known how antigens of the pathogenic organisms migrate from the mucosal tissues into the joints. The data presented here show that mononucle...

OBJECTIVE To examine whether reactive arthritis (ReA) known to occur after a urogenital infection with Chlamydia trachomatis can also follow an infection with Chlamydia pneumoniae, a recently described species of Chlamydiae that is a common cause of respiratory tract infections. METHODS Specific antibodies (microimmunofluorescence test) and lymphocyte proliferation to C trachomatis and C pneu...