We have used the technique of DNA-mediated gene transfer to examine cytotoxic T lymphocyte (CTL) recognition of the product of the cloned A/JAPAN/305/57 hemagglutinin (HA) gene in murine (L929) cells. Using both heterogeneous and homogeneous (clonal) populations of type A influenza-specific CTL, we have demonstrated that the HA molecule can serve as a target antigen for both the subtype-specifi...

Background/Aim: Sarcoidosis is a multisystem inflammatory disease characterized by the infiltration of various organs. Due to lack widely-accepted biomarker, researchers have explored alternative and previously unexplored parameters in sarcoidosis. This study aimed investigate utility markers, including systemic immune-inflammation index (SII) pan-immune-inflammation value (PIV), patients with ...

We used tuberculous pleuritis as a model to study the compartmentalization and potential immunoregulatory role of 1,25-dihydroxyvitamin D [1,25-(OH)2-D] in human granulomatous disease. In tuberculous pleuritis, mean concentrations of total 1,25-(OH)2-D were elevated in pleural fluid, compared to blood (67 pg/ml vs. 35 pg/ml). Concentrations of albumin, protein and 25-hydroxyvitamin D (25-OH-D) ...

Murine T cell reactivity with products of the minor lymphocyte stimulatory (Mls) locus correlates with the expression of particular variable (V) domains of the T cell receptor (TCR) beta chain. It was recently demonstrated that Mls antigens are encoded by an open reading frame (ORF) in the 3' long terminal repeat of either endogenous or exogenous mouse mammary tumor virus (MMTV). Immature thymo...

During B lymphocyte development, antibodies are assembled by random gene segment reassortment to produce a vast number of specificities. A potential disadvantage of this process is that some of the antibodies produced are self-reactive. We determined the prevalence of self-reactive antibody formation and its regulation in human B cells. A majority (55 to 75%) of all antibodies expressed by earl...

Aim: Community-acquired pneumonia (CAP) is a disease that affects children. One hundred fifty-five million children under five years are diagnosed with yearly, 20 hospitalized, and 2 die. Early diagnosis severity assessment reduce mortality morbidity. This study aimed to determine the effect of basic hemogram parameters, neutrophil-lymphocyte ratio (NLR), immature (IG) granulocyte, granulocyte ...

Objective: To determine the relationship between neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte (PLR) and mean platelet volume (MPV) with acute phase reactants in patients ankylosing spondylitis (AS) to show usability of these parameters activation periods follow-up disease.
 Material Method: The demographic data (age, gender) Bath Ankylosing Spondylitis Disease Activity Index (BA...

Abstract Background Hyperglycemia has been associated with increased inflammatory indexes and larger infarct sizes in patients obstructive acute myocardial infarction (obs-AMI). In contrast, no studies have explored these correlations non-obstructive (MINOCA). We investigated the relationship between hyperglycemia, inflammation size a cohort of AMI that included MINOCA. Methods Patients undergo...

Aim: Inflammatory process plays a critical role in the progression of aortic valve sclerosis (AVS). This study aims to evaluate haematological and biochemical inflammatory markers AVS patients.Methods: A retrospective observational was included consecutive 557 patients who underwent an echocardiogram between June 2021 September 2021. The population divided into two groups according presence AVS...

Background: Brucellosis is an inflammatory disease that may affect any organ or system. Objectives: The aim of this retrospective cross-sectional study was to investigate the predictive value novel and traditional markers for diagnosis brucellosis. Methods: demographic characteristics laboratory results 55 patients with confirmed brucellosis 60 healthy controls were analyzed compared. Blood cul...