The aim of the present study was to investigate whether and by which mechanism; histamine can induce state-dependent retrieval of passive avoidance task. The pre-training or pre-test intracerebroventricular (i.c.v.) injection of histamine (20µg/mouse) impaired retrieval, when it was tested 24 h later. In the animals, which retrieval was impaired due to histamine pre-training administration, pre...

objective: to evaluate the potentiality of ovcar–3 cell line of ovarian adenocarcinoma as a xenograft model for ovarian adenocarcinoma in nude mice. materials and methods: the cell line isolated from advanced human ovarian adenocarcinoma, were inoculated to eight nude mice and two months later. established tumors were transferred to pathology laboratory to be prepared by h&e; staining and immun...

Honey, propolis, and passionflower contain a flavone known as chrysin. Researchers are studying chrysin to prove its potential stop cancer cells growth. Chrysin therapeutic is of great interest numerous studies have been done illustrate this potential. It associated protein pathways effectively suppress tumor growth within the body. shown ability kill breast, prostate, lung, liver, stomach canc...

Many epithelial cancers rely on enhanced expression of the epidermal growth factor receptor (EGFR) to drive proliferation and survival pathways. Development of therapeutics to target EGFR signaling has been of high importance, and multiple examples have been approved for human use. However, many of the current small molecule or antibody-based therapeutics are of limited effectiveness due to the...

Steroid hormones mediate critical lineage-specific developmental and physiologic responses. They function by binding their cognate receptors, which are transcription factors that drive specific gene expression programs. The requirement of most prostate cancers for androgen and most breast cancers for estrogen has led to the development of endocrine therapies that block the action of these hormo...

  Introduction: Bombesin is a 14-aminoacid peptide isolated from frog skin. The mammalian counterparts of the frog peptide are neuromedin B (NMB) and gastrin-releasing peptide (GRP). Bombesin (BBN) is a peptide showing high affinity for the gastrin releasing peptide receptor (GRPr). Prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over...

E1A binding protein (p300) and its paralog CREB (CBP or CREBBP) are ubiquitously expressed histone acetyl transferases (HAT) that act by scaffolding as co-activator enhancer of different transcription factors like HIF1a, BRCA-1, p53, c-Myc, Estrogen receptor (ER) Androgen (AR). CBP p300 multidomain proteins harbour functional units imperative for chromatin remodelling Bromodomain (BD), Histone ...

Abstract Background Bladder cancer (BCa) and prostate (PCa) are frequent urothelial genital malignancies with a high ratio of morbidity mortality which more common among males. Since BCa PCa cases mainly diagnosed in advanced stages clinical complications, it is required to introduce the efficient early detection markers. Protein kinases critical factors involved various cellular processes such...

These experiments examined the effects of pre-test intra dorsal hippocampus (intra-CA1) administration of GABAA receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. Male NMRI mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received IP injections of either saline (10 mL/kg...