THROMBOLYTIC THERAPY in patients with acute myocardial infarction has received renewed attention since intracoronary infusion of streptokinase has been introduced into clinical practice. Efficacy of intracoronary infusion of streptokinase. In-tracoronary infusion of streptokinase results in recana-lization of approximately 75% of completely obstructed infarct-related vessels" 2 (table 1). Modif...

A prospective interventional study was carried out to compare the thrombolytic effect of streptokinase between diabetic and non-diabetic myocardial infarction patients. Out of 187 study subjects with acute ST segment elevation myocardial infarction, admitted at coronary care unit, 126 patients were nondiabetic and 61 patients were diabetic. Streptokinase was administered to all patients. Resolu...

OBJECTIVE To evaluate the role of intrapleural streptokinase in the management of complicated parapneumonic effusions in children. DESIGN Prospective comparative study. SETTING Cheng Kung University Hospital, a tertiary medical center in Tainan, Taiwan. PATIENTS AND METHODS We enrolled as our prospective study group 20 consecutive children with complicated parapneumonic effusions who rece...

BACKGROUND AND PURPOSE We used 99mTc-hexamethylpropyleneamine oxime single-photon emission computed tomography (SPECT) to study cerebral perfusion in patients treated with streptokinase for acute ischemic stroke in an open and prospective study. Our primary aims were (1) to compare the extent of reperfusion between patients who had received thrombolytic therapy and a control group studied durin...

.. Several strains of beta-hemolytic Streptococci produce streptokinase enzyme that can bind and activate human plasminogen to plasmin. Streptokinase degrades the fibrin lump by its explicit lysine joining site and so it is applied as a remedy in thrombolytic therapy. The purpose of the study was to subject wild strain of Streptococcus equisimilis to strain development technique, using random m...

The activation of human plasminogen by streptokinase has been the subject of extensive investigation (4-8). There appears to be general agreement that at least two enzymatic activities are demonstrable in streptokinase-plasminogen reaction mixtures. One is the proteolytic enzyme human plasmin, characterized in part by its ability to hydrolyze lysine and arginine esters and protein substrates su...

Fed-batch culture strategy is often used for increasing production of heterologous recombinant proteins in Escherichia coli. This study was initiated to investigate the effects of dissolved oxygen concentration (DOC), complex nitrogen sources and pH control agents on cell growth and intracellular expression of streptokinase (SK) in recombinant E. coli BL21(DE3). Increase in DOC set point from 3...

Peak serum C-reactive protein concentrations were measured in 146 patients randomized to receive streptokinase, alteplase, or a combination of streptokinase and alteplase in the GUSTO-I trial. Those receiving alteplase treatment had lower values than those receiving streptokinase or the combination treatment. Irrespective of treatment, complete reperfusion of the infarct-related artery (TIMI gr...

Rationale: The term “fragmentation of the QRS complex” denotes existence high-frequency potentials (spikes) in QRS-complex. It is either a marker for cardiac structural diseases inducing biventricular hypertrophy or any condition interfering with normally homogeneous depolarization status inside myocardium. An associated right ventricular infarction inferior maybe carry risk impact and serious ...

BACKGROUND The value of routine administration of intravenous thrombolytic agents during percutaneous transluminal coronary angioplasty (PTCA) therapy of acute myocardial infarction (MI) has not been determined. Therefore, we prospectively randomized 122 patients with evolving MI to PTCA therapy with or without adjunctive intravenous streptokinase therapy. METHODS AND RESULTS Patients with EC...