There are many difficulties distinguishing bacterial from viral meningitis that could be reasonably solved using biomarkers. The aim of this study was to evaluate lactate, procalcitonin (PCT), ferritin, serum-CRP (C-reactive protein), and other known biomarkers in differentiating bacterial meningitis from viral meningitis in children.All children aged 28 days to 14 years with suspected meningit...

The use of dexamethasone in the management of bacterial meningitis in adults remains controversial. This report illustrates the case of a 27-year-old male with severe meningococcal meningitis and meningococcemia who completely recovered after receiving antibiotics and dexamethasone. In adults with suspected bacterial meningitis, especially in high risk cases, the adjunctive use of dexamethasone...

Mollaret meningitis is a rare form of meningitis that is recurrent, aseptic, mild, and self-limiting. When initially described by Mollaret, this form of aseptic meningitis had no identifiable infecting agent. New sophisticated diagnostic tools have now identified Herpes simplex type 2 virus as the most commonly isolated agent. The case presented in this article is of a patient with a history of...

Appropriate, rapid and reliable laboratory tests are essential for the diagnosis and therapy of acute bacterial meningitis especially in children. The purpose of this study was to evaluate the diagnostic value of flowcytometric detection of CD64 surface marker on blood neutrophils in diagnosis of acute bacterial meningitis. Our work included 132 (74 males and 58 females) patients with suspected...

INTRODUCTION Bacterial meningitis is one of the most serious infectious diseases in childhood. AIM To identify the most common causes of bacterial meningitis in children in Tuzla Canton. PATIENTS AND METHODS This is a retrospective study which included 140 children, aged from 1 month to 14 years, treated at the Clinic for Infectious Diseases Tuzla, in the period 1999-2009, who had clinical ...

Despite the existence of antibiotic therapies against acute bacterial meningitis, patients with the disease continue to suffer significant morbidity and mortality in both high and low-income countries. Dilemmas exist for emergency medicine and primary-care providers who need to accurately diagnose patients with bacterial meningitis and then rapidly administer antibiotics and adjunctive therapie...

AIMS To determine the level of serum procalcitonin and cerebrospinal fluid cytokines in children with bacterial or viral meningitis and to document the use of these parameters in differential diagnosis. RESULTS Before the start of antibiotic treatment, serum procalcitonin and tumor necrosis factor alpha levels were found to be higher in acute bacterial meningitis compared with viral meningiti...

Objective. Bacterial meningitis is associated with significant morbidity and mortality if not diagnosed treated early. Isolation of the causative agent from cerebrospinal fluid culture gold standard for diagnosis this condition; however, it takes several days results to be available. The FilmArray™ Meningitis/Encephalitis (ME) panel a nucleic acid-based test that allows simultaneous detection 1...

OBJECTIVES Widespread use of Haemophilus influenzae type b (Hib) vaccines has dramatically reduced the burden of Hib disease throughout the Americas. Few studies have evaluated the impact of Hib vaccination on non-culture-confirmed disease. This study analyzed trends in probable bacterial meningitis before and after the introduction of Hib vaccine in the Dominican Republic and estimated vaccine...