background: recurrent pregnancy loss (rpl) has been defined as two or more miscarriages before 20 th week of gestation. it seems that il-27 may reduce inflammatory responses and affect the survival of the embryo during human pregnancy. il-27 polymorphisms may influence rpl by altering the levels or the activity of gene product. objective: we studied for the first time the association of il-27 -...

Background: Recurrent pregnancy loss (RPL) is an emotionally painful occurrence for couples and presents Obstetricians with a difficult clinical problem. Because primary etiology cannot be determined in roughly half of the instances, it irritating both patients obstetricians. The present study aimed to determine association antithrombin III gene (SERPINC1) mutation unexplained RPL.Methods: This...

Background/Aim: Recurrent pregnancy loss (RPL), described as the of two or more pregnancies before 24 weeks pregnancy, remains a concern for both couples and clinicians. Genetic factors tend to be strongly linked reproductive failure among different etiologies. Our goal was determine rates kinds chromosomal defects in who had repeated losses history miscarriage first trimester. Methods: This cr...

BACKGROUND Recurrent pregnancy loss (RPL) is a common health problem. The polymorphisms G20210A of prothrombin gene (FII G 20210A), and G 1691A of factor V gene (Factor V Leiden, FVL) are the most extensively studied thrombophilic mutations in association to recurrent miscarriage. OBJECTIVES To determine the frequency of FII G20210A and FVL polymorphisms as well as protein C and protein S def...

Objective To evaluate the prevalence of abnormal endocrine dysfunction for recurrent pregnancy loss (RPL) amongst patients with two versus three or more losses. Methods This cross-sectional study retrospectively collected pre-pregnancy data 537 women diagnosed RPL in Shengjing Hospital China Medical University from 2017 to 2022, including baseline and test results factors. Several included this...

Objective : The prognostic value of peripheral natural killer (pNK) cells, as a screening test in women with recurrent pregnancy loss (RPL) and unexplained infertility is still a matter for discussion. The aim of this study was to compare the percentage of circulating CD56+NK cells, CD69 and perforin markers between women with unexplained infertility and RPL with healthy control group. Material...

BACKGROUND Recurrent pregnancy loss (RPL) is defined as two or more miscarriages before the 20(th) week of gestation and its etiology is unknown in 50% of the cases. Interleukin 6 is an immune mediator, plays a regulatory role in embryo implantation and placental development. OBJECTIVE The purpose was to assess the association between IL-6 -634C/G polymorphism and, susceptibility to idiopathi...

BACKGROUND Reproductive outcome studies of couples with a history of recurrent pregnancy loss (RPL) associated with a maternal or paternal carrier of a structural chromosome rearrangement are limited. Correlation of carrier status and cytogenetics of miscarriage specimens is critical to estimate subsequent pregnancy outcome. METHODS Couples found to have a structural chromosome rearrangement ...

It is known that sperm samples from recurrent pregnancy loss (RPL) couples have an increase in their sperm DNA fragmentation (SDF), but no studies have been performed in order to identify differences between single stranded SDF (ssSDF) and double stranded SDF (dsSDF) in these patients. This could be relevant because the type of DNA damage could have different effects. Semen samples were classif...

introduction: a factor known to cause thrombophilia in women with recurrent pregnancy loss (rpl) is the a1298c polymorphism of methylenetetrahydrofolate reductase gene (mthfr). this study aimed to determine the association between rpl and this polymorphism in iranian patients. methods: in this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...