Fever is routinely faced during medical practice. Although it is part of the immune response against pathogens, it is often seen as deleterious and a source of discomfort leading to the use of antipyretic drugs. However, few clinical data support this common practice. On the contrary, to date, results tilt in favor of the beneficial effect of fever, such as a better immune response and inhibiti...

Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention of AMS. For each dose, risk ratios were aggregated using a Mantel-Haenszel fix...

OBJECTIVE To determine whether poor reporting of methods in randomised controlled trials reflects on poor methods. DESIGN Observational study. SETTING Reports of randomised controlled trials conducted by the Radiation Therapy Oncology Group since its establishment in 1968. PARTICIPANTS The Radiation Therapy Oncology Group. Outcome measures Content of reports compared with the design featu...

Coronary Event Reduction in Diabetic Patients With Myocardial Infarction To the Editor: It would be very helpful if we were able to see further analysis of the study by Goldberg et al.1 The analysis presented was for the group as a whole, which included significant variations in baseline cholesterol levels. It would be helpful if we could see an analysis similar to that performed in the LIPID s...