Stroke is a major public health concern. The lack of effective therapies heightens the need for new therapeutic targets. Mammalian brain has the ability to rewire itself to restore lost functionalities. Promoting regenerative repair, including neurogenesis and dendritic remodeling, may offer a new therapeutic strategy for the treatment of stroke. Here, we report that interaction of neuronal nit...

Spinal cord injury triggers a complex set of events that lead to tissue healing without the restoration of normal function due to the poor regenerative capacity of the spinal cord. Nevertheless, current knowledge about the intrinsic regenerative ability of central nervous system axons, when in a supportive environment, has made the prospect of treating spinal cord injury a reality. Among the ra...

Hydraulic regenerative braking system is an important branch of hybrid technology, which has the advantage of high power density and the ability to accept the high rates/high frequencies of charging and discharging, therefore hydraulic regenerative braking technology is well suited for off-road vehicles and heavy-duty trucks. Relatively lower energy density and complicated coordinating operatio...

This work uncovers novel mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans and affect both embryonic and adult stem cells. Specifically, we have examined the effects of aged muscle and systemic niches on key molecular identifiers of regenerative potential of human embryonic stem cells (hESCs) and post-natal muscle stem cells (satellite cells)....

Recent research in the vaccine and immunotherapy fields has revealed that biomaterials have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. Intriguingly, new studies reveal these responses are influenced by the physicochemical properties of the material. Nearly all of this work has been done in the vaccine and immunotherapy fields, but there is ...

Oral leukoplakia is one of the common precancerous lesions in oral mucosa. To compare the biological characteristics and regenerative capacities of mesenchymal stem cells (MSCs) from oral leukoplakia (epithelial hyperplasia and dysplasia) and normal oral mucosa, MSCs were isolated by enzyme digestion. Then these cells were identified by the expression of MSC related markers, STRO-1, CD105 and C...

personalized medicine as a novel field of medicine refers to the prescription of specific therapeutics procedure for an individual. this approach has established based on pharmacogenetic and pharmacogenomic information and data. the terms precision and personalized medicines are sometimes applied interchangeably. however, there has been a shift from “personalized medicine” towards “precision me...

Regenerative braking can extend the driving range and reduce PM emissions from abrasion for battery electric heavy-duty trucks (BETs). The composite control strategy including torque distribution dynamic coordinated four-axle BET equipped with electromechanical system is studied. A segmented proposed to maximize energy recovery while ensuring stability. simulation results reveal that shows bett...

the suppression of the regenerative chatter phenomenon in turning process via the variation of the frequency and amplitude of the spindle motor excitation is carried out in this research. a programmable inverter is employed for variable periodic excitation of the spindle motor. a set of turning experiments is designed and performed on a number of conical work pieces both in constant spindle spe...