نتایج جستجو برای: regulates leptin in ovariectomized rat

تعداد نتایج: 17040355  

Journal: :International journal of molecular medicine 2006
Witold Malendowicz Marcin Rucinski Anna S Belloni Agnieszka Ziolkowska Gastone G Nussdorfer Zbigniew Kwias

We have recently demonstrated the expression of leptin and leptin receptor (Ob-R) isoforms a, b, c, e and f in the rat seminal vesicles and prostate. The aim of the present study was to provide a semiquantitative real-time PCR estimation of leptin/Ob-R isoform mRNA expression in the seminal vesicles and individual components of rat prostate, and to ascertain the in vitro effects of leptin on pr...

Journal: :Cancer research 2015
Chao-Ching Chang Meng-Ju Wu Jer-Yen Yang Ignacio G Camarillo Chun-Ju Chang

Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Here we report how leptin, an obesity-associated adipokine, regulates a transcriptional pathway to silence a genetic program of epithelial homeostasis in breast cancer stem-like cells (CSC) that promotes malignant progression. Using genome-wide ChIP-seq and RNA expression profiling, we defined a r...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Daniel M Purdham Min-Xu Zou Venkatesh Rajapurohitam Morris Karmazyn

Leptin, the 16-kDa peptide hormone product of the ob gene, is produced primarily by adipocytes and was initially thought to exert its effects exclusively through actions on the hypothalamus via distinct leptin receptors termed OB-R. However, recent data show that leptin is produced elsewhere and that receptors are present in many other tissues. Using real-time PCR, we determined whether leptin ...

Journal: :The Kurume medical journal 2010
Jiro Miyajima Tokumasa Hayashi Koujiro Saito Shizuka Iida Kei Matsuoka

It is well known that the incidence of urinary stones is higher in men than women. Although it is believed that the lower incidence of urinary stones in women is due to a protective effect of estrogen, the mechanisms remain unclear. To clarify the relation between female sex hormones and stone matrix protein, we examined the interaction of estrogen receptor-α (ERα), estrogen receptor-related re...

Journal: :Carcinogenesis 1997
J D Shull T J Spady M C Snyder S L Johansson K L Pennington

We have examined the ability of 17beta-estradiol (E2) to induce development of mammary cancers in the female ACI rat. Continuous treatment with E2, delivered through release from s.c. Silastic tubing implants containing 27.5 mg crystalline hormone, resulted in rapid development of palpable mammary tumors in ovary-intact ACI rats. In a population of 21 E2-treated rats, palpable tumors were first...

Journal: :Journal of leukocyte biology 2000
G Fantuzzi R Faggioni

Leptin, the product of the ob gene, is a pleiotropic molecule that regulates food intake as well as metabolic and endocrine functions. Leptin also plays a regulatory role in immunity, inflammation, and hematopoiesis. Alterations in immune and inflammatory responses are present in leptin- or leptin-receptor-deficient animals, as well as during starvation and malnutrition, two conditions characte...

Journal: :Postepy higieny i medycyny doswiadczalnej 2011
Patrycja Gogga Joanna Karbowska Włodzimierz Meissner Zdzisław Kochan

Leptin is a hormone secreted primarily by adipose tissue and its blood levels depend on the amount of fat stored in adipocytes. Leptin has a wide range of physiological effects. Acting directly or through the sympathetic nervous system it participates in the regulation of energy metabolism. Leptin inhibits synthesis of triacylglycerols in the liver, adipose tissue and skeletal muscles, thus red...

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