Methods The results of 28 relapse prevention trials, including a total of 5233 patients, were summarised in a meta-analysis. Studies were included if they focused on patients with anxiety disorder who responded to antidepressants, if they randomised patients to either continuing antidepressants or switching to placebo, and if they compared relapse rates or time to relapse between patients who c...

PURPOSE When using state-transition Markov models to simulate risk of recurrent events over time, incorporating dependence on higher numbers of prior episodes can increase model complexity, yet failing to capture this event history may bias model outcomes. This analysis assessed the tradeoffs between model bias and complexity when evaluating risks of recurrent events in Markov models. METHODS...

Background: Central Nervous System (CNS) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, Intrathecal chemotherapy and cranial irradiation. The purpose of this study was to compare the effectiveness of intrathecal (IT) CNS chemotherapy alone versus combination of IT chemotherapy with cranial irradiation for prevention of CNS rel...

methamphetamine (ma) is a potent, addictive psychostimulant that has dramatic effects on the central nervous system (cns). the onset of methamphetamine use has been linked to heightened attention, and chronic methamphetamine use has been associated with deficits in different aspects of attention that can significantly persist into abstinence. attention deficits in chronic methamphetamine users ...