Abstract Background: Renal transplantation (RT) is the transplantation of a kidney into a patient with end-stage renal disease and has become the treatment of choice for most patients with end-stage renal disease. The knowledge of renal vascular variations is of a great importance for the surgeons who approach the kidneys from the retroperitoneal o...

BACKGROUND Interleukin 18 (IL-18) is a pro-inflammatory cytokine that mediates fibrotic renal injury during obstruction. Macrophages are a well-known source of IL-18; however, renal tubular epithelial cells are also a potential source of this cytokine. We hypothesized that IL-18 is predominantly a renal tubular cell product and is produced during renal obstruction independent of macrophage infi...

Objective: To assess the histological changes of the aorta, the renal arteries and the renal parenchyma in swine, induced by a metalic uncovered stent implanted in transrenal position in the abdominal aorta. Methods: Ten pigs with a mean weight of 86.6 kg and mean age of 6 months underwent implantation of metal stent graft placed in the aorta at the level of the renal arteries after 100 days of...

Among several factors determining secretion of renin is mean arterial pressure (Skinner, McCubbin, and Page, 1964). Plasma renin is, in some instances, increased in renal artery stenosis (Helmer, 1964; Brown et al., 1964; Veyrat et al., 1964): and it is probable that this increase is due to lowered arterial pressure beyond the obstruction. In coarctation of the aorta there is a similar discrepa...

Misseri, R., D. R. Meldrum, C. A. Dinarello, P. Dagher, K. L. Hile, R. C. Rink, and K. K. Meldrum. TNFmediates obstructioninduced renal tubular cell apoptosis and proapoptotic signaling. Am J Physiol Renal Physiol 288: F406–F411, 2005. First published October 26, 2004; doi:10.1152/ajprenal.00099.2004.—Obstruction of the upper urinary tract induces a progressive loss in renal mass through apopto...

Docherty, Neil G., Orfhlaith E. O’Sullivan, Declan A. Healy, John M. Fitzpatrick, and R. William G. Watson. Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction. Am J Physiol Renal Physiol 290: F4–F13, 2006; doi:10.1152/ ajprenal.00045.2005.—Ureteric obstruction is frequently encountered in primary care urolo...

Single umbilical artery (SUA) is the most common abnormality of the umbilical cord. It is associated with an increased incidence of atresia of hollow organs, renal abnormalities, limb reduction defects and spontaneous abortions. The aetiopathogenesis, although unknown, is attributed to vascular disruption. In this study, 15 foetal autopsies with SUA, seen over a one-year period have been review...

certain benefits are clearly associated with the use of off-pump coronary artery bypass grafting (cabg) as compared with the on-pump cabg. the superiority is more evident in patients with multiple co morbidities including renal failure.we reviewed the medical records of a 67-year-old male with a past medical history that was significant for multiple cardiovascular diseases and new-onset end-sta...