BACKGROUND: It is well described that diabetes mellitus is a hypercoagulable state. It is also known that patients with renal dysfunction have impaired platelet aggregation and function. It is not well described how renal dysfunction affects the hypercoagulability associated with diabetes. This post-hoc sub-group analysis compares platelet function, clot structure and thrombin generation time a...

Renal dysfunction is common in patients with heart failure and is associated with high morbidity and mortality. Cardiac and renal dysfunction may worsen each other through multiple mechanisms such as fluid overload and increased venous pressure, hypo-perfusion, neurohormonal and inflammatory activation, and concomitant treatment. The interaction between cardiac and renal dysfunction may be crit...

BACKGROUND Crizotinib is an approved tyrosine kinase inhibitor in the treatment of advanced-stage non-small-cell lung cancer patients with anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangement. Renal dysfunction after crizotinib administration was recently reported, but the physiopathological explanation and the safety in patients with preexisting renal dysfunction are still not clea...

β-thalassemia is one of the most common hereditary diseases in Egypt. The leading causes renal dysfunction thalassemic patients include chronic anemia, iron overload from repeated blood transfusions, and kidney-induced damage use chelators.

background and purpose: posterior urethral valve (puv) is one of the most severe urinary tract anomalies presenting as antenatal hydronephrosis that could lead to severe dilatation and functional impairment of one or both kidneys. the aim of this study was to analyze our experience on patients with a diagnosis of puv. materials and methods: in this prospective study neonates with a diagnosis of...

It is well documented that patients with renal failure suffer from some degree of cardiovascular illnesses.(1) In chronic uremia, cardiovascular disease manifests as concentric left ventricular hypertrophy, left ventricular dilatation, systolic dysfunction, or diastolic dysfunction.(2) These conditions create a predisposition for developing heart failure, arrhythmias, and sudden death,(3) which...

background: previous studies have shown increases in endothelin (et) concentration of plasma and renal tissues in acute renal failure (arf).  et has a potent vasoconstrictor effect, through binding with its et a receptors, and may play some roles in renal hemodynamic dysfunction in arf. objective: to examine the beneficial effect of a selective et a -receptor antagonist on renal dysfunction and...

We report two patients in whom hypothyroidism was considered to cause renal dysfunction. Case 1 was a 65-year-old woman who stopped taking levothyroxine sodium for hypothyroidism. After 6 months, she developed proteinuria, edema, weight gain, and renal dysfunction. Renal biopsy revealed focal segmental proliferative glomerulonephritis. After re-administration of levothyroxine sodium, thyroid fu...

Introduction: Renal ischemia reperfusion (I/R) caused kidney injury gender dependently. High fat diet (HFD) contributes the development of renal dysfunction. L-arginine (L-arg) and regular exercise are recognized to be protective in I/R and lipotoxicity. We compared the role of aerobic exercise and L-arg supplementation against renal I/R in male and female rats fed with HFD. Methods: 54 adult ...

This review summarizes the available evidence concerning the relationship between renal dysfunction and cardiovascular risk in non-diabetic patients. Based on numerous studies, there remains no more doubt today, that even minor renal dysfunction, as reflected by microalbuminuria and/or decreased estimated glomerular filtration rate, causes a dramatic increase in cardiovascular risk. Renal dysfu...