EM P L O Y I N G electroneurographic technics, Bein and McCubbin and Page have shown that a significant portion of the acute cardiovascular effects of reserpine is mediated centrally. The mechanism involved is not known but, since serotonin has been shown to inhibit central synaptic transmission, Brodie et al. and Shore et al. have suggested that the sedative effect of reserpine might depend up...

島本 暉朗 ・松尾 高明 ・服部 圭佑 ・本庄 俊 The intravenous injection of 0.5 to 3.0 mg/kg of traps-2-phenylcyclopropylamine maleate (SKF-385) in the anesthetized dog produces the pressor effect which is prevented by the adrenolytic doses of tolazoline and dibenamine (1). However, the repetition of the doses of SKF-385 exerts the depressor effect which is totally abolished by the pretreat ment with reserpine. The...

Rauwolfia serpentina medicinal value well known in various system of medicine all over the world. Reserpine is an indole alkaloid and is important constituent of Rauwolfia which is reported to posses anti hypertensive and tranquilizing activity. In the present study High Performance Thin Layer Chromatography has been developed for quantification of Reserpine in Rauwolfia and its allied preparat...

depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. th...

The carotid bodies from control, reserpine-treated, and hypoxia-treated hamsters were fixed with phosphate-buffered glutaraldehyde and osmium tetroxide, s-Collidine-buffered osmium tetroxide, or phosphate-buffered glutaraldehyde followed by potassium dichromate incubation. Following glutaraldehyde-osmium tetroxide fixation no differences in density or population of the electron-opaque granules ...

Bovine chromaffin cell cultures were treated with either reserpine or alpha-methyl-p-tyrosine for up to 10 days. Afterwards the cells were harvested and the degree of proteolytic processing of secretogranin II, chromogranin A and chromogranin B was determined by immunoblotting and HPLC followed by RIA. There was a significant increase in the proteolysis of all three chromogranins after 4-6 days...

In this study was found that inflammation in interstitial lung tissue of mice C57Bl/6 after intratracheal injection of the bleomycin is accompanied by the increase of the bone marrow and circulating blood cells with the phenotype (CD3, CD45R (B220), Ly6C, Ly6G (Gr1), CD11b (Mac1), TER-119), Sca-1, c-Kit, CD34 (hematopoietic stem cells (HSCs)) and hematopoietic progenitor cells (granulocyte-eryt...