It has been reported that reserpine causes a prolonged hypertension after the pretreatment of ephedrine and metamphetamine46'47. This hypertension was observed in the previous experiments and the mechanism of the drugs producing the hypertension was discussed. Pheniprazine was proposed as a monoamine oxidase inhibitor by Horita , and reserpine produced a prolonged hypertension after the adminis...

Mismatch repair proteins modulate the cytotoxicity of several chemotherapeutic agents. We have recently proposed a "death conformation" of the MutS homologous proteins that is distinguishable from their "repair conformation." This conformation can be induced by a small molecule, reserpine, leading to DNA-independent cell death. We investigated the parameters for a small reserpine-like molecule ...

Once a day push pull osmotic tablets containing pramipexole as an antiparkinson’s agent were developed and evaluated for in vivo efficacy. Push pull osmotic tablets are bilayered tablets consisting of pull layer (drug layer) and push layer (polymer layer) coated with semipermeable cellulose acetate membrane containing water leaching pore forming agents. To determine the in vivo efficacy of form...

Wistar rats were successively reared in cold at 5 degrees C from 1969 to 1984. The historical changes observed in these rats were reported. The cold-adapted rats reared in cold for 8 to 11 successive generations (C8-11G) were examined on their cold tolerance and non-shivering thermogenesis. C8-11G rats showed greater nonshivering thermogenesis than that of the warm-adapted control group (W), an...

Abstract Rauwolfia tetraphylla L., is an important medicinal plant in Apocynaceae family and recognized as alternative source to serpentina terms of anti-hypertensive alkaloid production i.e. reserpine. In view this, the present study conducted estimate reserpine content different parts (leaf, stem root) field grown plants (2 years old), tissue cultured plantlets (R 1 ) (two months old) cell su...

We developed a simplified assay for estimating efflux by measuring the effect of reserpine on the growth of Streptococcus pneumoniae and Staphylococcus aureus over 7 h. Reserpine enhanced ciprofloxacin and levofloxacin 17 to 68%. The hydrophobic drug trovafloxacin and the drug moxifloxacin, with a bulky C-7 substituent but hydrophilicity similar to that of levofloxacin, showed little (0 to 11%)...

1 The concentrations of p- and m-tyramine were measured in the caudate nucleus of the rat brain following subcutaneous injection of reserpine or intraventricular injection of 6-hydroxydopamine, beta-Phenylethylamine was analysed in the hypothalamus after reserpine. 2 Endogenous levels of p-tyramine and m-tyramine in the caudate nucleus, and beta-phenylethylamine in the hypothalamus were 8.02, 2...

Epidemiological studies of reserpine use and breast cancer have generally found only small increases in breast cancer risk, even after long-term use. Prolactin levels in short-term reserpine users have been reported to be in the range of those of lactating women, levels which rodent experiments suggest should greatly increase breast cancer incidence. We measured prolactin levels in 15 women who...

The treatment of hypertension with reserpine is described. When used alone it produced adequate falls of blood pressure in ten out of forty patients. The combination of reserpine with veratrum did not increase the hypotensive effects of reserpine alone. The combination of reserpine with pentapyrrolidinium increases the effectiveness of the pentapyrrolidinium and lessens its para-sympathetic sid...