نتایج جستجو برای: resistance components

تعداد نتایج: 753957  

2010
Carlos Juárez-López Miguel Klünder-Klünder Patricia Medina-Bravo Adrián Madrigal-Azcárate Eliezer Mass-Díaz Samuel Flores-Huerta

BACKGROUND Insulin resistance is the primary metabolic disorder associated with obesity; yet little is known about its role as a determinant of the metabolic syndrome in obese children. The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among obese children and adolescents. METHODS An analytical, c...

2012
James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Giuseppe Montalto Melchiorre Cervello Ferdinando Nicoletti Paolo Fagone Grazia Malaponte Maria C. Mazzarino Saverio Candido Massimo Libra Jörg Bäsecke Sanja Mijatovic Danijela Maksimovic-Ivanic Michele Milella Agostino Tafuri Lucio Cocco Camilla Evangelisti Francesca Chiarini Alberto M. Martelli

The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, MEK1, DUSP5, PP2A, PIK3CA, PIK3R1, PIK3R4, PIK3R5, IRS4, AKT, NFKB1, MTOR, PTEN, TSC1, and TSC2 may also be activated/inactivated by mutations or epigenetic silencing. Upstrea...

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