When excised tendons are subjected to a prolonged load, whether constant or oscillatory, fatigue damage accumulates, leading eventually to rupture. 'Fatigue quality', assessed by the time-to-rupture under a given stress, was found to vary hugely among the tendons of a wallaby hind limb. This material property correlates with the varied stresses to which tendons from different anatomical sites a...

the incremental sheet metal forming (ismf) process is a new and flexible method that is well suited for small batch production or prototyping. this paper studies the use of the finite element method in the incremental forming process of aa1050 sheets to investigate the influence of tool diameter, vertical step size, and friction coefficient on forming force, spring-back, and thickness distribut...

The adsorption of phosphatidylcholine (PC) vesicles (30, 50, and 100 nm nominal diameters) and of dye-labeled PC vesicles (labeled with 6% Texas Red fluorophore (TR) and encapsulated carboxy fluorescein (CF)) to glass surfaces was studied by contact mode atomic force microscopy in aqueous buffer. These studies were performed in part to unravel details of the previously observed isolated rupture...

We combine dynamic self-consistent field theory with the string method to calculate the minimum energy path to membrane pore formation and rupture. In the regime where nucleation can occur on experimentally relevant time scales, the structure of the critical nucleus is between a solvophilic stalk and a locally thinned membrane. Classical nucleation theory fails to capture these molecular detail...

Background: This study aimed to introduce a modified technique for minimally invasive Achilles tendon (AT) rupture repairusing gift box sutures. The preliminary clinical and functional outcomes were investigated among a number of patients.Methods: In a consecutive case series study, 24 patients with acute AT rupture underwent modified minimally invasiveAT repair using two mini...

an ideal orthodontic force system should exert continuous light force. thus, many efforts have been made to improve the memory characteristics of elastomeric chains. the aim of this study was to compare elastomeric chains (ecs) claimed by their manufacturers to offer high memory with traditional ones according to their force-extension diagrams.in this in-vitro study, ecs were divided into six g...

Dynamic force spectroscopy was used to test force-induced dissociation of the complex between the integrin α7β1 and the bacterial protein invasin. Both proteins were used in truncated forms comprising the respective binding sites. Using the biomembrane force-probe, the bond system was exposed to 14 different loading rates ranging from 18 pN/s to 5.3 nN/s. At each rate, bond rupture spectra were...

Curvatures in the most probable rupture force (f*) versus log-loading rate (log r(f)) observed in dynamic force spectroscopy (DFS) on biomolecular complexes are interpreted using a one-dimensional free energy profile with multiple barriers or a single barrier with force-dependent transition state. Here, we provide a criterion to select one scenario over another. If the rupture dynamics occurs b...