Action potential duration (APD) restitution, which relates APD to the preceding diastolic interval (DI), is a useful tool for predicting the onset of abnormal cardiac rhythms. However, it is known that different pacing protocols lead to different APD restitution curves (RCs). This phenomenon, known as APD rate dependence, is a consequence of memory in the tissue. In addition to APD restitution,...

Early epithelial restitution is an important repair modality in the gut mucosa and occurs as a consequence of epithelial cell migration. Canonical transient receptor potential-1 (TRPC1) functions as a store-operated Ca2+ channel (SOCs) in intestinal epithelial cells (IECs) and regulates intestinal restitution, but the exact upstream signals initiating TRPC1 activation after mucosal injury remai...

Egan, Laurence J., Ana de Lecea, Evan D. Lehrman, Gennett M. Myhre, Lars Eckmann, and Martin F. Kagnoff. Nuclear factorB activation promotes restitution of wounded intestinal epithelial monolayers. Am J Physiol Cell Physiol 285: C1028–C1035, 2003. First published June 25, 2003; 10.1152/ajpcell.00167.2003.—Epithelial restitution, the movement of wound-edge cells into an area of epithelial cell d...

We measure kinematic coefficients of normal restitution in head-on collisions of two identical small spheres of acrylic, ceramic or steel suspended by thin resilient strands at low enough impact speeds for adhesion to lower the restitution. We observe such reduction at speeds consistent with an apparent adhesion surface energy larger than expected.

Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution properties have promise as a new paradigm for preventing fibrillation.

BACKGROUND The mechanism by which structural barriers promote wave break and fibrillation is unclear. Conduction velocity (CV) restitution is an important determinant of wave break. Abnormal CV restitution is associated with ventricular fibrillation in patients with heart disease and arises preferentially in fibrotic myocardium. We hypothesize that tissue discontinuities imposed by structural b...

The National Automotive Sampling System/Crashworthiness Database System (NASS/CDS) is a well-known digital repository containing statistics on hundreds of thousands of vehicle crashes that occurred over the past 30 years. Many of the NASS crashes contain estimates of Delta-v calculated using WinSMASH, a common software reconstruction package. Recent work indicates that WinSMASH typically undere...

Chung HK, Rathor N, Wang SR, Wang JY, Rao JN. RhoA enhances store-operated Ca entry and intestinal epithelial restitution by interacting with TRPC1 after wounding. Am J Physiol Gastrointest Liver Physiol 309: G759–G767, 2015. First published September 3, 2015; doi:10.1152/ajpgi.00185.2015.—Early mucosal restitution occurs as a consequence of epithelial cell migration to resealing of superficial...