BACKGROUND Whereas conventional white cassava roots are devoid of provitamin A, biofortified yellow varieties are naturally rich in β-carotene, the primary provitamin A carotenoid. OBJECTIVE We assessed the effect of consuming yellow cassava on serum retinol concentration in Kenyan schoolchildren with marginal vitamin A status. DESIGN We randomly allocated 342 children aged 5-13 y to receiv...

BACKGROUND The role of retinol (vitamin A) in breast cancer prognosis has never been investigated in postmenopausal women. We prospectively assessed the long-term prognostic role of retinol plasma levels in a cohort of postmenopausal breast cancer patients. PATIENTS AND METHODS We investigated 208 women self-reported as postmenopausal operated on for T(1-2)N(0)M(0) breast cancer who participa...

PURPOSE The purpose of this study was to measure the effects of mutations on the retinol binding capability of human Repeat 1 of interphotoreceptor retinoid-binding protein (IRBP). First, we predicted important functional amino acids by several computer programs. We also noted the lack of shared functions between Tail-specific protease (Tsp) and IRBP, which bear sequence similarity, and this ai...

The fat-soluble vitamin A has, of necessity, to be transported in the body by carrier proteins since it functions in an aqueous environment. At the same time, control of the distribution of the alcohol form, via specific retinol-binding proteins (RBP), provides additional physiological advantages. The concentration of the amphiphilic molecule is more easily limited in tissue fluids where, if fr...

How is retinoic acid produced? In vertebrates, vitamin A, in the form of retinyl esters, is stored mainly in the liver as well as in the lungs, kidneys and bone marrow. Retinol, bound to the retinolbinding protein (RBP), enters the circulatory system in order to reach cells that require retinoic acid. The retinol–RBP complex enters the cells through the RBP receptor (STRA6). Within the cells, r...

Chemical peels are widely used in cosmetological and dermatological treatments. Salicylic acid Jessner’s solution often acne therapy. Moreover, both of these combination with retinol the therapy hyperpigmentation, wrinkles, photodamage, acne. The aim this research was to evaluate effectiveness treatment reduce lesions. Two 23-year-old women vulgaris lesions participated study. Each them receive...

Vitamin A is essential for vision and the growth/differentiation of almost all human organs. Plasma retinol binding protein (RBP) is the principle and specific carrier of vitamin A in the blood. Here we describe an optimized technique to produce and purify holo-RBP and two real-time monitoring techniques to study the transport of vitamin A by the high-affinity RBP receptor STRA6. The first tech...

OBJECTIVES To determine colostrum retinol levels in breastfeeding women from the city of Natal, state of Rio Grande do Norte, Brazil, and to investigate the relationship between retinol levels in colostrum and child, maternal and socioeconomic variables. METHODS Forty-two healthy women aged 18 to 39 years were evaluated 48 hours after delivery. Socioeconomic, anthropometric, and dietary data ...