Network-on-Chip (NoC) has been proposed as an alternative to bus-based schemes to achieve high performance and scalability in System-on-Chip (SoC) design. Performance evaluation of On-Chip Interconnect (OCI) architectures is widely based on simulation which becomes computationally expensive, especially for largescale NoCs. In this paper, we study

Abstract Background Obsessive-compulsive disorder (OCD) is a common mental affecting millions of people. Its onset and peak are during late teens making university students priority target. Medical student perhaps at greater risk for developing OCD while corona COVID-19 expected to more exaggerate symptoms mainly with extra hygiene cleanliness practices. The aim the study was estimate prevalenc...

Interleukin 6 (IL-6) and insulin-like growth factor I (IGF-I) induce proliferative and antiapoptotic responses in multiple myeloma (MM) plasma cells. Because these cytokines may activate the phosphatidylinositol 3-kinase (PI 3-K)/AKT kinase pathway in other cell types, we investigated the role of PI 3-K/AKT in MM cell responses. IGF-I effectively activated PI 3-K in 8226 and OCI-My5 MM cells, b...

Purpose: Recently, seven diffuse large B-cell lymphoma (DLBCL) genotypes were defined, among which the A53 type showed adverse outcomes. Thus, it is necessary to explore promising anticancer drugs and therapies for TP53 dysfunction patients. APR-246 a compound combat mutant p53 in solid hematological tumors, but effect of on DLBCL remains unclear. Methods: A set 2464 cases from multiple cohorts...

INTRODUCTION The peripheral perfusion index (PI) is a noninvasive numerical value of peripheral perfusion, and the transcutaneous oxygen challenge test (OCT) is defined as the degree of transcutaneous partial pressure of oxygen (PtcO2) response to 1.0 FiO2. The value of noninvasive monitoring peripheral perfusion to predict outcome remains to be established in septic patients after resuscitatio...

BACKGROUND Chronic kidney disease (CKD) is a common medical condition among children and obsessive-compulsive disorder (OCD) is a frequent, chronic, costly, and disabling disorder among them. OBJECTIVES The aim of this study was to investigate obsessive-compulsive disorder (OCD) in children with early stages of CKD, and to compare it with the occurrence of OCD in healthy children. PATIENTS ...

The renal handling of immunoreactive insulin was studied in the isolated perfused normothermic rat kidney to determine (a) the relative contributions of glomerular clearance and peritubular clearance to the renal clearance of insulin under different conditions, (b) what metabolic factors influence the ability of tubular cells to remove insulin from the glomerular filtrate and the peritubular ci...

Golgi alpha-mannosidase II (GMII), a member of glycoside hydrolase family 38, cleaves two mannosyl residues from GlcNAcMan(5)GlcNAc(2) as part of the N-linked glycosylation pathway. To elucidate the molecular and electronic details of the reaction mechanism, in particular the conformation of the substrate at the transition state, we performed quantum mechanics/molecular mechanics metadynamics s...

OBJECTIVE The present study aimed to examine the efficacy of metacognitive therapy in treatment of patients with pure obsession. METHOD Six patients suffering from pure obsession were selected using purposeful sampling method and were included after meeting the inclusion criteria of the study. Patients were assessed using the structured clinical interview for DSM- IV Axis I disorder - patient...