Whether these two complexes have different functions During cell division, daughter cells must receive one is currently unknown. Binding of the cohesin complex and only one copy of each and every chromosome. To to discrete chromosomal regions occurs prior to S accomplish this, a cell has to not only duplicate each phase, and the establishment of cohesion between the chromosome, but it must also...

DNA replication is performed by a multiprotein complex known as the ‘replisome,’ which assembled and regulated in cell cycle–dependent manner.Hypomorphic mutations of components replisome lead to defective development, reduced growth, altered tissue homeostasis.Whole-genome sequencing studies significantly expanded repertoire mendelian diseases caused mutation machinery.Phenotypic analysis mech...

DNA replication is central to all extant cellular organisms. There are substantial functional similarities between the bacterial and the archaeal/eukaryotic replication machineries, including but not limited to defined origins, replication bidirectionality, RNA primers and leading and lagging strand synthesis. However, several core components of the bacterial replication machinery are unrelated...