Rho family GTPases play important roles in a variety of cellular processes, including actin cytoskeleton reorganization, transcription activation, and DNA synthesis. Dominant negative mutants of Rho GTPases, such as T17NRac1, that block the endogenous Rho protein activation by sequestering upstream guanine nucleotide exchange factors (GEFs) have been widely used to implicate specific members of...

We have isolated a rifampicin-resistant mutant of Escherichia coli RNA polymerase that restores transcription termination in strains with a defective rho protein. In such strains, the mutant RNA polymerase terminates transcription at normally rho-dependent sites at the end of the trp operon, in bacteriophage lambda, and within the lac operon. In addition, a strain with this mutant RNA polymeras...

Rho-associated kinase (Rho-kinase), which is activated by the small GTPase Rho, regulates formation of stress fibers and focal adhesions, myosin fiber organization, and neurite retraction through the phosphorylation of cytoskeletal proteins, including myosin light chain, the ERM family proteins (ezrin, radixin, and moesin) and adducin. Rho-kinase was found to phosphorylate a type III intermedia...

Although radiation-induced bystander effects have been well described over the past decade, the mechanisms of the signaling processes involved in the bystander phenomenon remain unclear. In the present study, using the Columbia University charged particle microbeam, we found that mitochondrial DNA-depleted human skin fibroblasts (rho(o)) showed a higher bystander mutagenic response in confluent...

generalized geraghty type fuzzy mappings oncomplete metric spaces are introduced and a fixed point theorem thatgeneralizes some recent comparable results for fuzzy mappings incontemporary literature is obtained. example is provided to show thevalidity of obtained results over comparable classical results for fuzzymappings in fixed point theory. as an application, existence of coincidencefuzzy p...

We recently demonstrated that in MCF-7 breast cancer cells, insulin promoted the phosphorylation and activation of geranylgeranyltransferase I (GGTI-I), increased the amounts of geranylgeranylated Rho-A and potentiated the transactivating activity of lysophosphatidic acid (LPA) (Chappell, J., Golovchenko, I., Wall, K., Stjernholm, R., Leitner, J., Goalstone, M., and Draznin, B. (2000) J. Biol. ...

Our laboratory has recently demonstrated that insulin induces relaxation of vascular smooth muscle cells (VSMCs) by activating myosin-bound phosphatase (MBP) and by inhibiting Rho kinase (Begum N, Duddy N, Sandu OA, Reinzie J, and Ragolia L. Mol Endocrinol 14: 1365-1376, 2000). In this study, we tested the hypothesis that insulin via the nitric oxide (NO)/cGMP pathway may inactivate Rho, result...

We study the pseudo-differential operator $$\begin{aligned} T_a f\left( x\right) =\int _{\mathbb {R}^n}e^{ix\cdot \xi }a\left( x,\xi \right) \widehat{f}\left( \,\text {d}\xi , \end{aligned}$$where symbol a is in Hörmander class \(S^{m}_{\rho ,1}\) or more generally rough \(L^{\infty }S^{m}_{\rho }\) with \(m\in \mathbb {R}\) and \(\rho \in [0,1]\). It known that \(T_a\) bounded on \(L^1(\mathbb...

Let $X$ be the product of a surface satisfying $b_2=\rho$ and curve over finite field. We study strong form integral Tate conjecture for $1$-cycles on $X$. generalize give unconditional proofs several results our previous paper with J.-L. Colliot-Th\'el\`ene.

We discuss about the generalized $F$-contraction mappings in partially ordered metric spaces. For this, we first introduce the notion of ordered weakly $F$-contraction mapping. We also present some fixed point results about this type of mapping in partially ordered metric spaces. Next, we introduce the notion of $acute{mathrm{C}}$iri$acute{mathrm{c}}$ type generalized ordered weakly $F$-contrac...