Systemically primed BALB/c mice developed severe diarrhea after repeated oral administration of ovalbumin (OVA). Histological analysis demonstrated that dramatic infiltration of eosinophils and mast cells occurred in the large intestine but not in the small intestine of mice with diarrhea. Interestingly, CD4(+) alphabeta T cells of the large intestine secreted IL-4 and IL-13 at high levels. Ide...

Mice with fibroblast-specific expression of TAP-1 were generated by expressing the TAP-1 transgene under the control of the fibroblast-specific protein (FSP) 1 promoter/enhancer on TAP-1-deficient background. MHC class I expression in primary fibroblast cultures isolated from the resulting strain mimicked that of wild-type counterparts. MHC class I was detected in both types of fibroblasts foll...

Toll-like receptor (TLR)-dependent pathways control the production of IFNalphabeta, a key cytokine in innate immune control of viruses including mouse cytomegalovirus (MCMV). The lymphotoxin (LT) alphabeta-LTbeta receptor signaling pathway is also critical for defense against MCMV and thought to aid in the IFNbeta response. We find that upon MCMV infection, mice deficient for lymphotoxin (LT)al...

Two structurally distinct forms of RNA-directed DNA polymerase from avian myeloblastosis virus were resolved by chromatography on phosphocellulose and purified. In addition to RNA-directed DNA polymerase activity, both enzymes had ribonuclease H (RNase H) activity, which degraded the RNA moiety of RNA.DNA hybrids. As determined by sodium dodecyl sulfate-polyacrylamide disc-gel electrophoresis, ...

Drosophila mushroom bodies (MB) are bilaterally symmetric multilobed brain structures required for olfactory memory. Previous studies suggested that neurotransmission from MB neurons is only required for memory retrieval. Our unexpected observation that Dorsal Paired Medial (DPM) neurons, which project only to MB neurons, are required during memory storage but not during acquisition or retrieva...

we introduce center-like subsets z*(r,f), z**(r,f) and z1(r,f), where r is a ring and f is a map from r to r. for f a derivation or a non-identity epimorphism and r a suitably-chosen prime or semiprime ring, we prove that these sets coincide with the center of r.

for an arbitrary ring $r$, the zero-divisor graph of $r$, denoted by $gamma (r)$, is an undirected simple graph that its vertices are all nonzero zero-divisors of $r$ in which any two vertices $x$ and $y$ are adjacent if and only if either $xy=0$ or $yx=0$. it is well-known that for any commutative ring $r$, $gamma (r) cong gamma (t(r))$ where $t(r)$ is the (total) quotient ring of $r$. in this...

let r be a prime ring with extended centroid c, h a generalized derivation of r and n ⩾ 1 a xed integer. in this paper we study the situations: (1) if (h(xy))n = (h(x))n(h(y))n for all x; y 2 r; (2) obtain some related result in case r is a noncommutative banach algebra and h is continuous or spectrally bounded.

a ring $r$ is a strongly clean ring if every element in $r$ is the sum of an idempotent and a unit that commutate. we construct some classes of strongly clean rings which have stable range one. it is shown that such cleanness of $2 imes 2$ matrices over commutative local rings is completely determined in terms of solvability of quadratic equations.