In brain development, excitatory and inhibitory neurons show distinct types of migration, radial migration and tangential migration, respectively. Whether these two types of migration are operated by similar cellular mechanisms remains unclear. Here we examined mice deficient in mDia, a Rho-regulated actin nucleator, in neuronal migration. mDia deficiency impaired tangential migration of cortic...

The series of acoustic emission events from loaded rock samples were studied by means of correlation analysis. As characteristic parameters of the correlation functions were chosen: the first values of the autocorrelation coefficients, the number of positive autocorrelation coefficients and the linearity of the autocorrelation function. The increase in the values of the autocorrelation coeffici...

electro-facies is a unit of the vertical sediments sequence on the wire-line logs that can be differentiated from the upper and lower units. for detection of the electro-facies interval in kangan and upper dalan formations in south pars gas field, wire-line log and core data analysis (wells a, b, c and d) were used. note, only core data analysis in well a were available. first, thin-sections st...

a typical iranian carbonate matrix block surrounded by an open fracture was modeled in order to understand the fracture-matrix interaction and realize how to model the interaction best. the modeling was carried out by using a fine-scaled eclipse model in the single porosity mode (the fractures were explicitly modeled). the model was extended to a stack of 6 matrix blocks to understand block-to-...

The effects of listening to different types of music on perceived and physiological indicators of relaxation were evaluated. Fifty-six undergraduate students, 24 males and 32 females, mean age of 21, were randomly assigned to listen to classical, hard rock, self-selected relaxing music, or no music. Participants' relaxation level, skin temperature, muscle tension and heart rate were evaluated b...

A typical Iranian carbonate matrix block surrounded by an open fracture was modeled in order to understand the fracture-matrix interaction and realize how to model the interaction best. The modeling was carried out by using a fine-scaled Eclipse model in the single porosity mode (the fractures were explicitly modeled). The model was extended to a stack of 6 matrix blocks to understand block-to-...

BACKGROUND AND PURPOSE Combretastatin A-4 3-O-phosphate (CA4P) is in clinical trial as a tumour vascular disrupting agent (VDA) but the cause of blood flow disruption is unclear. We tested the hypothesis that activation of Rho/Rho kinase (ROCK) is fundamental to the effects of this drug in vivo. EXPERIMENTAL APPROACH Mouse models of human colorectal carcinoma (SW1222 and LS174T) were used. Ef...

The serine/threonine kinases, Rho‑associated protein kinase I and II (ROCK I and II), regulate the cytoskeleton by acting downstream of the small GTPase, Rho, and have been implicated in tumorigenesis and cancer metastasis. Inhibition of ROCK signaling has been shown to suppress the invasion and migration of several types of cancer cells. In this study, the effect of the ROCK inhibitor, Y‑27632...

This paper describes the application of a new methodology to estimate permeability of clastic rock formations based on the numerical simulation of the physics of mudfiltrate invasion. The methodology assumes a key well with a complete suite of well logs and rock-core laboratory measurements of porosity, permeability, capillary pressure, and relative permeability. For additional wells in the sam...

Knowledge about the permeability of surrounding rock (salt rock and mudstone interlayer) is an important topic, which acts as a key parameter to characterize the tightness of gas storage. The goal of experiments that test the permeability of gas storage facilities in rock salt is to develop a synthetic analogue to use as a permeability model. To address the permeability of a mudstone/salt layer...