The SMC harbours a class of hot nitrogen-sequence Wolf-Rayet stars (WNE) that display only relatively weak broad emission lines. This indicates low mass-loss rates and makes them also hard to detect. However, such stars are possible emitters of strong He Lyman continua that in turn could ionize observable He iii regions, i.e. highly excited H ii regions emitting nebular He iiλ4686 emission. We ...

OBJECTIVES The purpose of this study was to assess the pregnancy-related cardiovascular risk in LQT1 patients. BACKGROUND Only 1 study addressed this issue in genotyped patients and reported that the highest risk is for LQT2 patients. METHODS This case-control study, performed in a cohort of patients from 22 families affected by LQT1 and all sharing the common KCNQ1-A341V mutation, involved...

Anna Starowicz-Filip1, Olga Milczarek2, Stanisław Kwiatkowski2 , Barbara Bętkowska-Korpała1, Katarzyna Prochwicz3: 1Medical Psychology Department, Psychiatry, Jagiellonian University Medical College; 2Neurosurgery Ward, Children’s University Hospital in Cracow; 3Institute of Psychology, Jagiellonian University. Correspondence address: [email protected] Cerebellar cognitive affective syndrom...

BACKGROUND Genetic testing can diagnose long-QT syndrome (LQTS) in asymptomatic relatives of patients with an identified mutation; however, it is costly and subject to availability. The accuracy of a simple algorithm that incorporates resting and exercise ECG parameters for screening LQTS in asymptomatic relatives was evaluated, with genetic testing as the gold standard. METHODS AND RESULTS A...

Dear Editor, I read with great interest the recent article by Saif et al1 in a recent issue of your esteemed journal. The article is highly thought provoking. Interestingly, the past few years have seen the identifi cation of a number of pathological conditions resulting because of mutations in the KCNQ1 gene. For instance, increased disease severity is seen in patients with Long QT syndrome (L...

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, 660 route orders at the molecular level. des Lucioles, Sophia Antipolis, 06560 Valbonne and 1INSERM U153, A recent flurry of publications described multiple Groupe Hospitalier Pitié-Salpêtrière, Institut de Myologie, mutations within two K channel genes that cause the 47 boulevard de l’Hôpital, 75651 Paris Cedex, France RW and JLN syndr...

Guanfacine extended release (GXR) and atomoxetine (ATX) are nonstimulant treatments for attention-deficit/hyperactivity disorder (ADHD). As nonstimulant treatments are often used after stimulants in ADHD, GXR was assessed relative to prior stimulant treatment in a randomized controlled trial (RCT), in which ATX was included as a reference arm, and in the open-label phase of a randomized-withdra...

The study assesses complexity of the cardiac control directed to the sinus node and to ventricles in long QT syndrome type 1 (LQT1) patients with KCNQ1-A341V mutation. Complexity was assessed via refined multiscale entropy (RMSE) computed over the beat-to-beat variability series of heart period (HP) and QT interval. HP and QT interval were approximated respectively as the temporal distance betw...

THE increasing importance of geriatric medicine in the medical curriculum is shown by the fact that, whereas ten years ago there were no short soft-cover textbooks on the subject, in 1981 second editions of three of these books appeared. The second edition of this book has the same basic format as the first and is a product of the author's wide knowledge and experience of the subject. Revisions...

The empirical analysis of multiproduct pricing suffers from a lack of clear theoretical guidance and appropriate data, limitations which often render traditional regression-based analyses impractical. This paper analyzes ticket, parking, and concession pricing in Major League Baseball for the period 1991-2003 using a new methodology based on principal components, which allows inferences to be f...