Family-based study designs are again becoming popular as new next-generation sequencing technologies make whole-exome and whole-genome sequencing projects economically and temporally feasible. Here we evaluate the statistical properties of linkage analyses and family-based tests of association for the Genetic Analysis Workshop 17 mini-exome sequence data. Based on our results, the linkage metho...

Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular SNAr, alkylation with silica-supported oligomeric benzyl (Si-OBPn) and triazole (Si-OTPn) phosphates, and intermolecular SNAr addition with a number of secondary amines in one-pot...

the old Union song, “Which side are you on?”1 To paraphrase Huck, you don’t know about David Lodge without you have read Small World, a wonderful and zany romp through the academic conference circuit. There we met Morris Zapp, a thinly disguised Stanley Fish, professor of English at Euphoria State, an even more thinly disguised Berkeley. I read these lines as a new and quite untenured professor:

Ru-based olefin metathesis catalysts containing carbohydrate-derived NHCs from glucose and galactose were synthesized and characterized by NMR spectroscopy. 2D-NMR spectroscopy revealed the presence of Ru-C (benzylidene) rotamers at RT and the rate of rotation was measured using magnetization transfer and VT-NMR spectroscopy. The catalysts were found to be effective at ring-opening metathesis p...

The ROCM reactions of exo- and endo-2-cyano-7-oxanorbornenes with allyl alcohol or allyl acetate promoted by different ruthenium alkylidene catalysts were studied. The stereochemical outcome of the reactions was established. The issues concerning chemo- (ROCM vs ROMP), regio- (1-2- vs 1-3-product formation), and stereo- (E/Z isomerism) selectivity of reactions under various conditions are discu...

Fluorescent, aqueous-soluble, crosslinked dendronized polyols (CDPs) are obtained through a sequential process involving ring-opening metathesis polymerization (ROMP), intra-chain ring-closing metathesis (RCM), and hydrolysis. This general strategy improves the quantum yields (QYs), brightness, and photostability of five common fluorophores whose emission wavelengths cover 150 nm. Additionally,...

Ileana Dragutan 1,‡, Valerian Dragutan 1,*,‡, Petru Filip 1,‡, Bogdan C. Simionescu 2,*,‡ and Albert Demonceau 3,‡ 1 Institute of Organic Chemistry, Romanian Academy, 202B Spl. Independentei, P. O. Box 35-108, Bucharest 060023, Romania; [email protected] (I.D.); [email protected] (P.F.) 2 Petru Poni Institute of Macromolecular Chemistry, Romanian Academy, Iasi 700487, Romania; bcsimion@icm...

Front Cover: In article number 2100238 by Dario R. Dekel, Charles E. Diesendruck and co-workers look at the ligand valency effect on alkaline stability of metallopolymer anion-exchange membranes. fuel cells electrolyzers, aggressive environment decomposes organic cations metallopolymers present a promising alternative. ROMP polynorbornenes with multidentate pyridine-Nickel complexes are used to...