Various human cancers express elevated levels of the receptor tyrosine kinases Met or Ron and v6-containing isoforms of CD44. The activation of Met and Ron requires the presence of such CD44 v6-containing isoforms that act as coreceptors. Three amino acids within the v6 sequence were identified by mutational analysis to be essential for the coreceptor function: EWQ in the rat sequence and RWH i...

The Research Octane Number (RON) and the Motor (MON) are primary fuel properties that characterize gasoline’s knock resistance in spark ignition engines. utility of these two metrics, however, has been questioned with advancements engine technologies significantly change thermochemical environment inside cylinder. Index, OI = (1-K)·RON + K·MON, therefore proposed to modern engines where K weigh...

The tyrosine kinase receptor Ron has been implicated in several types of cancer, including overexpression in human breast cancer. This is the first report describing the effect of Ron signaling on tumorigenesis and metastasis in a mouse model of breast cancer. Mice with a targeted deletion of the Ron tyrosine kinase signaling domain (TK-/-) were crossed to mice expressing the polyoma virus midd...

The receptor tyrosine kinase RON (recepteur d'origine nantais), a member of the MET proto-oncogene family, has been implicated in the pathogenesis of certain epithelial cancers including lung adenocarcinomas. To determine the oncogenic potential of RON, transgenic mice were generated using the surfactant protein C promoter to express human wild-type RON in the distal lung epithelial cells. The ...

Avoiding knock is the major design constraint for spark ignition engines because of the unacceptable noise and engine damage associated with it. Hence, the Research and Motor Octane Number (RON and MON) tests were established in 1928 such that a fuel with a higher RON and MON is less likely to knock than a fuel with a lower value. However, engine and fuel technology has evolved since 1928, and ...

INTRODUCTION We measured duration mismatch negativity (dMMN), P3a, and reorienting negativity (RON) in subjects with at-risk mental state (ARMS), patients with first-episode or chronic schizophrenia, and healthy volunteers. The main interest was to determine if these event-related potentials provide a biomarker associated with progression to overt schizophrenia in ARMS subjects. METHODS Ninet...