MOTIVATION We present a new probabilistic model of the evolution of RNA-, DNA-, or protein-like sequences and a software tool, Rose, that implements this model. Guided by an evolutionary tree, a family of related sequences is created from a common ancestor sequence by insertion, deletion and substitution of characters. During this artificial evolutionary process, the 'true' history is logged an...

The stopped-flow mixing technique was used to develop a very fast, sensitive and accurate method for determining total proteins. The method is based on the lower fluorescence of Rose Bengal caused by binding of the dye to the proteins. The decrease in the fluorescence intensity, measured at 572 nm with excitation 555 nm, was linearly related to protein concentration from 1.3 to 24.5 micrograms ...

This paper introduces a family of tetravalent graphs called rose window graphs, denoted by Rn(a, r), and investigates their symmetry properties. Four families of these graphs are shown to be edge-transitive and it is conjectured that every Rn(a, r) which is edge-transitive belongs to one of these families. Proofs and conjectures about the size of a dart-stabilizer and about regular maps contain...

It shows him in his Public Health Service uniform sometime after 1915, when he attained the rank of Assistant Surgeon General. Carter was a quarantine officer and a field epidemiologist, best known for his discovery in 1898 of the extrinsic incubation period of yellow fever. His discovery led directly to the historic finding by Reed, Carroll, Agra-monte, and Lazear in 1900 that mosquitoes are t...

On June 2, 2015, Irwin (Ernie) Rose died quietly in his sleep at age 88, after a long and fruitful lifetime of sleuthing for the secrets of life at the molecular level. Truly great scientists are much more than the sum of their publications and awards. This is especially true for Ernie who, when informed that he had been awarded the 2004 Nobel Prize in Chemistry, wondered aloud whether he reall...

Hierarchical structure is ubiquitous in data across many domains. There are many hierarchical clustering methods, frequently used by domain experts, which strive to discover this structure. However, most of these methods limit discoverable hierarchies to those with binary branching structure. This limitation, while computationally convenient, is often undesirable. In this paper we explore a Bay...