Soluble royal jelly protein is a candidate factor responsible for mammiferous cell proliferation. Major royal jelly protein 1 (MRJP1), which consists of oligomeric and monomeric forms, is an abundant proliferative protein in royal jelly. We previously reported that MRJP1 oligomer has biochemical heat resistance. Therefore, in the present study, we investigated the effects of several heat treatm...

Abstract Drone brood homogenate and compositions based on it are gaining popularity as functional food products biologically active additives. It has antioxidant, androgenic, anabolic, sedative, antidepressant, immunotropic, cosmetic other properties. Royal jelly drone have a pronounced biological activity, they contain large amount of decenoic acids, sulfhydryl groups, proteins, peptides subst...

As antimicrobial drugs destroy microorganisms or stop their growth, they are used to treat infections. Due the increasing resistance of infectious agents drugs, there is a need find new natural products with properties. Natural such as bee honey, propolis, pollen, bread, and royal jelly important numerous different active biological features, antiviral among them. The aim this study was investi...

Soluble royal jelly (RJ) proteins (SRJPs) include the major RJ protein (MRJP) family, which contribute to the physiological actions of RJ. Although SRJPs are prepared using conventional methods involving dialysis and centrifugation, dialysis is a time-consuming process. We have therefore developed a simple method to isolate SRJPs from RJ. This new method produces 20-fold higher levels of SRJPs ...

The discovery that the royal jelly of the honeybee contains large quantities of nucleic acids raises the question, "Where do these nucleic acids come from?" A review of pertinent literature strongly suggests that the same mechanism is involved as in the case of the extrachromosomal DNA of amphibian oocytes.

Four antimicrobial peptides were purified from Royal Jelly of honeybees, by using reverse phase-HPLC and sequenced by using Q-Tof-MS/MS: PFKLSLHL-NH(2) (Jelleine-I), TPFKLSLHL-NH(2) (Jelleine-II), EPFKLSLHL-NH(2) (Jelleine-III), and TPFKLSLH-NH(2) (Jelleine-IV). The peptides were synthesized on-solid phase, purified and submitted to different biological assays: antimicrobial activity, mast cell...

OBJECTIVES To evaluate the synergistic action of starch on the antibacterial activity of royal jelly (RJ), a comparative method of adding RJ with and without starch to culture media was used. METHODS Strains of Staphylococcus aureus and Escherichia coli have been used to determine the minimum inhibitory concentration (MIC) of a variety of freshly reaped RJ. In a second step, lower concentrati...

BACKGROUND Young larvae of the honey bee (Apis mellifera) are totipotent; they can become either queens (reproductives) or workers (largely sterile helpers). DNA methylation has been shown to play an important role in this differentiation. In this study, we examine the contributions of diet and cell size to caste differentiation. METHODOLOGY/PRINCIPAL FINDINGS We measured the activity and gen...

Trauma risk management (TRiM) is an intensive posttraumatic stress disorder (PTSD) psychoeducational management strategy based on peer-group risk assessment developed by the UK Royal Navy (RN). TRiM seeks to modify attitudes about PTSD, stress, and help-seeking and trains military personnel to identify at-risk individuals and refer them for early intervention. This quasiexperimental study found...