Systems for Rapid Response to Earthquakes (RRE) aim at providing reliable and near-real time ground-motion loss estimates following an earthquake, in order help authorities taking appropriate actions when needed. The purpose of this study is review the state-of-the-art RRE systems, focusing first on tools methods that have been developed shake-map computation (i.e., into account seismic recordi...

A series of substituted phenanthridine derivatives has been synthesized by converting the amines at the 3- and 8-positions of ethidium bromide into guanidine, pyrrole, urea, and various substituted ureas. The resulting derivatives exhibit unique spectral properties that change upon binding nucleic acids. The compounds were analyzed for their ability to inhibit the HIV-1 Rev-Rev Response Element...

During the screening of the natural products for their ability to inhibit the binding of REV (regulation of virion expression) protein to [33P] labeled RRE (REV responsive element) RNA, two novel fungal metabolites, harziphilone and fleephilone, were isolated from the butanol-methanol (1:1) extract of the fermentation broth of Trichoderma harzianum by bioassay guided fractionation. The structur...

Expression of human immunodeficiency virus type 1 (HIV-1) structural proteins requires the presence of the viral trans-activator protein Rev. Rev is localized in the nucleus and binds specifically to the Rev response element (RRE) sequence in viral RNA. Furthermore, the interaction of the Rev activation domain with a cellular cofactor is essential for Rev function in vivo. Using cross-linking e...

Water retention curves (WRCs) and hydraulic conductivity functions (HCFs) are critical soil-specific characteristics necessary for modeling the movement of water in soils using Richardson-Richards equation (RRE). Well-established laboratory measurement methods WRCs HCFs not usually suitable simulating field-scale soil moisture dynamics because scale mismatch. Hence, inverse solution RRE must be...

The minimal polynomial extrapolation (MPE) and reduced rank extrapolation (RRE) are two very effective techniques that have been used in accelerating the convergence of vector sequences, such as those that are obtained from iterative solution of linear and nonlinear systems of equations. Their definitions involve some linear least squares problems, and this causes difficulties in their numerica...

Human immunodeficiency virus type I (HIV-1) encodes a regulatory protein, Rev, which is required for cytoplasmic expression of incompletely spliced viral mRNA. Rev activity is mediated through specific binding to a cis-acting Rev responsive element (RRE) located within the env region of HIV-1. A monomer Rev binding site corresponding to 37 nucleotides of the RRE (IIB RNA) was studied by RNA foo...

Saint Mary’s College students w ill select class officers from a variety of tickets tomorrow. The Class o f 1994 w ill have four tickets to choose from this T hu rsda y in c lu d in g c u rre n t ju n io r class p re s id e n t, Beth Petrovic. A ll candidates w ant to sup­ p o rt the Saint M ary ’s sesquicentennial com m ittee’s events surrounding the Class of 1994. P e trov ic , i f e lected ,...

HIV-1 Rev protein directs nuclear export of pre-mRNAs and mRNAs containing its binding site, the Rev response element (RRE). To define how Rev acts, we used conjugates between bovine serum albumin (BSA) and peptides comprising the Rev activation domain (BSA-R). BSA-R inhibited Rev-mediated nuclear RNA export, whereas a mutant activation domain peptide conjugate did not. BSA-R did not affect the...