نتایج جستجو برای: rsk method
تعداد نتایج: 1630648 فیلتر نتایج به سال:
Friction occurring in the area of contact between sheet metal and tool forming is one factors determining quality surface drawpiece formability workpiece. Knowledge friction conditions allows optimal to be determined terms lubrication applied pressures. The article presents results experimental studies EN AW-2024-T3 Alclad sheets using a special device simulating sheet–tool blank-holder during ...
A Richardson variety X α in the Orthogonal Grassmannian is defined to be the intersection of a Schubert variety X in the Orthogonal Grassmannian and a opposite Schubert variety Xα therein. We give an explicit description of the initial ideal (with respect to certain conveniently chosen term order) for the ideal of the tangent cone at any T -fixed point of X γ α, thus generalizing a result of Ra...
To define the functional pathways regulating epithelial cell migration, we performed a genome-wide RNAi screen using 55,000 pooled lentiviral shRNAs targeting ∼11,000 genes, selecting for transduced cells with increased motility. A stringent validation protocol generated a set of 31 genes representing diverse pathways whose knockdown dramatically enhances cellular migration. Some of these pathw...
ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips
Signaling by extracellular signal-regulated kinase (ERK) plays an essential role in the induction of cell motility, but the precise mechanism underlying such regulation has remained elusive. We recently identified SH3P2 as a negative regulator of cell motility whose function is inhibited by p90 ribosomal S6 kinase (RSK)-mediated phosphorylation downstream of ERK. We here show that myosin 1E (My...
We study the classification of 2-dimensional scale-invariant rigid special Kahler (RSK) geometries, which potentially describe the Coulomb branches of N=2 supersymmetric field theories in four dimensions. We show that this classification is equivalent to the solution of a set of polynomial equations by using an integrability condition for the central charge, scale invariance, constraints coming...
Potent selective cyclooxygenase-2 (COX-2) inhibitors are effective in controlling inflammatory disorders but are associated with cardiovascular complications. Their clinical use has been severely limited. We propose that transcription-based inhibition of COX-2 expression represents a therapeutic strategy that may circumvent the undesired complications of COX-2 inhibitors. Reported data from sev...
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