PDZ domains are typical examples of binding motifs mediating the formation of protein-protein assemblies in many different cells. A quantitative characterization of the mechanisms intertwining structure, chemistry, and dynamics with the PDZ function represent a challenge in molecular biology. Here, we investigated the influence of native state topology on the thermodynamics and dissociation kin...

Earth's deepest earthquakes occur in subducting oceanic lithosphere, where temperatures are lower than in ambient mantle. On 24 May 2013, a magnitude 8.3 earthquake ruptured a 180-kilometer-long fault within the subducting Pacific plate about 609 kilometers below the Sea of Okhotsk. Global seismic P wave recordings indicate a radiated seismic energy of ~1.5 × 10(17) joules. A rupture velocity o...

Black lipid membranes (BLM) less than 90 A thick have been shown to be the most realistic approach to biological membrane models. This paper describes the formation characteristics, optical properties, and thermodynamics of BLM at water/oil/water bifaces. In particular, the nature of the Plateau-Gibbs border which supports the black membrane is analyzed in some detail. The formation of BLM at t...

The transfer of hydride, proton, or H atom between substrate and cofactor in enzymes has been extensively studied for many systems, both experimentally and computationally. A simple equation for the reaction rate, an analog of an equation obtained earlier for electron transfer rates, is obtained, but now containing an approximate analytic expression for the bond rupture-bond forming feature of ...

Background High-energy blunt chest injury will bring out severe cardiac and pulmonary injuries. It may cause cardiac contusion, rupture, cardiac valve dysfunction, and aortic laceration [1]. As traumatic hemopericardium occurs, ultrasound is a convenient and reliable tool for diagnosis. We presented a 55-year-old male victim of blunt chest trauma complicated with hemopericardium, cardiac tampon...

On 16 September 2015, a great (Mw 8.3) interplate thrust earthquake ruptured offshore Illapel, Chile, producing a 4.7-m local tsunami. The last major rupture in the region was a 1943 MS 7.9 event. Seismic methods for rapidly characterizing the source process, of value for tsunami warning, were applied. The source moment tensor could be obtained robustly by W-phase inversion both within minutes ...

Two cases of orbital injuries caused by the jet of water from an irrigation sprinkler are described; they were of a type not previously reported. The jet of water, possessing high kinetic energy, stretched the orbital tissues and resulted in a rupture which followed the anatomical seams. Thus there was no bleeding, but oedema was present. The eyeball was also injured.

The Wenchuan earthquake of 12 May 2008 is the most destructive earthquake in China in the past 30 years in terms of property damage and human losses. In order to understand the earthquake process and the geo-morphological factors affecting the seismic hazard, we simulated the strong ground motion caused by the earthquake, incorporating three-dimensional (3D) earth structure, finite-fault ruptur...

BACKGROUND Occlusion of blood vessels using high-intensity focused ultrasound (HIFU) is a potential treatment for arteriovenous malformations and other neurovascular disorders. However, attempting HIFU-induced vessel occlusion can also cause vessel rupture, resulting in hemorrhage. Possible rupture mechanisms include mechanical effects of acoustic cavitation and heating of the vessel wall. ME...

The 28 June 1992 Big Bear earthquake occurred at 15:05:21 GMT and is considered to be an af tershock of the earlier Mw = 7.3 Landers earthquake. F rom overall aftershock locations and long-period focal studies, rupture is general ly assumed to have propagated northeast. No surface rupture was found, however , and the mainshock locations determined f rom both strong motion and TERRAscope data ar...