Vanoxonin, a new inhibitor of thymidylate synthetase, was found in cultured broths of the strain MG245-CF2 classified as Saccharopolyspora hirsuta. Vanoxonin, C18H25N3O9, was obtained as colorless powder. Vanoxonin forms a vanadium complex which exhibits a strong inhibition against thymidylate synthetase. The concentration for 50% inhibition of the enzyme (IC50) was 0.7 micrograms/ml.

We report the development of an electrotransformation method applicable to all strains of Saccharopolyspora erythraea examined to date. Vegetatively grown mycelia were rendered electrocompetent by subjecting mycelial suspensions to ultrasound pulses. The protocol provides an alternative route for the introduction of DNA into filamentous microorganisms otherwise recalcitrant to transformation te...

Erythromycin is produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics. It is basic and readily forms salts with acids but it is the base which is microbiologically active. Erythromycin base is (3R *, 4S *, 5S *, 6R *, 7R *, 9R *, 11R *, 12R *, 13S *, 14R *)-4­ [(2,6-Dideoxy-3-C-methyl3-O-methyl--L-ribo-hexopyran...

Study of Population Structure Capparis Spinosa and Analysis Morphological Traits using ISSR SCoT Markers

Sporeamicin A is a new erythromycin-type antibiotic isolated from a species of Saccharopolyspora. It was active in vitro against a wide variety of Gram-positive bacteria. In vitro studies indicated that the sporeamicin A was stable in the presence of human serum, although it was bound to serum proteins. Sporeamicin A was effective in the mouse protection test against Staphylococcus aureus, Stre...

background pycnocycla spinosa decne. ex boiss is an aromatic plant which showed relaxant effects on isolated ileum contractions and antidiarrheal activity. thirty four components have been extracted from p. spinosa essential oil, of which several major constituents were found to show seasonal variation. objectives the aim of this work is to evaluate the diurnal variation of its oil constituents...

hydroalcoholic extract of pycnocycla spinosa has spasmolytic effect in vitro and antidiarrhoeal action in vivo . the aim of this research was to separate fractions of total hydroalcoholic extract of p. spinosa guided by their spasmolytic activity. aerial parts of p. spinosa were extracted with ethanol. the concentrated extract was subjected to column chromatography and thin layer chromatography...