The expression of sex hormone receptors in some tumors suggests a role for these receptors in tumor pathogenesis and therapy. Previous studies of the expression of estrogen and progesterone receptors in salivary gland tumors have reported conflicting results. We evaluated the immunohistochemical expression of androgen, estrogen, and progesterone receptors (AR, ER, and PR) in a series of 78 form...

Sjögren’s syndrome (SS) is an autoimmune disease in which exocrine glands including the salivary gland are targeted and destroyed by the immune system (Voulgarelis and Tzioufas, 2010). SS and the side-effects of γ-radiation therapies for head and neck cancers cause salivary gland dysfunction, in particular hyposalivation (Atkinson et al., 2005; Fox, 1998; O'Sullivan and Higginson, 2010). Among ...

Transcription factors drive organogenesis, from the initiation of cell fate decisions to the maintenance and implementation of these decisions. The Drosophila embryonic salivary gland provides an excellent platform for unraveling the underlying transcriptional networks of organ development because Drosophila is relatively unencumbered by significant genetic redundancy. The highly conserved FoxA...

The Drosophila salivary gland is proving to be an excellent experimental system for understanding how cells commit to specific developmental programs and, once committed, how cells implement such decisions. Through genetic studies, the factors that determine where salivary glands will form, the number of cells committed to a salivary gland fate, and the distinction between the two major cell ty...

Saliva plays an essential role in maintaining oral health. Alterations in salivary function lead to compromise of oral tissues and functions and have a large impact on a patient’s quality of life. Reductions in salivary flow most commonly manifest as symptoms of oral dryness. This subjective complaint of dry mouth is termed xerostomia, whereas objective alterations in salivary performance, quan...

Naphthyl esterase and platelet-activating factor (PAF)-acetylhydrolase activities were detected in the salivary glands of the cat flea, Ctenocephalides felis. Salivary naphthyl esterase activity is disgorged during exploratory probing. Whole extracts of salivary glands contain esterase activity against the short-chain naphthyl esters alpha-naphthyl acetate (approximately 210pmol/min/gland pair;...

abstract salivary gland tumors are among the pathologies in the head and neck that may be challenging in diagnosis and treatment. most benign tumors occur in the parotid gland. pleomorphic adenoma is the most common type. basal cell adenoma is a subtype of the monomorphic adenoma with rare occurrence. proper diagnosis and clinical evaluation by the use of radiography can lead the physician to t...

Abstract Introduction In the last fifteen years, thanks to refinement of non–invasive diagnostic techniques, there has been a clear increase in diagnosis amyloidosis. From this need arises establishment specific out–patients department order guarantee best path and treatment. Methods Since 2018 we have begun suspect cardiac amyloidosis hospitalized patients with heart failure preserved ejection...