Co-crystallization of 4,4'-methyl-enediphenyl-amine (MDA) and 5-sulfosalicylic acid (5-H(2)SSA) yields the title salt, C(13)H(16)N(2) (2+)·2C(7)H(5)O(6)S(-)·H(2)O. The asymmetric unit is comprised of one dication, two anions and one water mol-ecule. In the crystal structure, the components of the salt are linked by a combination of inter-molecular O-H⋯O, N-H⋯O and weak C-H⋯O hydrogen bonds into...

Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically controlled crystallization pr...

We describe a microfluidic device for mapping phase diagrams of aqueous samples as a function of concentration and temperature. This double-layer (poly)dimethylsiloxane (PDMS) device contains a storage layer, in which hundreds of nanolitre sized aqueous droplets can be simultaneously formed and stored. A second layer, separated by a thin, water-permeable PDMS-membrane contains twelve reservoir ...

Studying the earliest stages of precipitation at the nanoscale is technically challenging but quite valuable as such phenomena reflect important processes such as crystallization and biomineralization. Using a quartz nanopipette as a nanoreactor, we induced precipitation of an insoluble salt to generate oscillating current blockades. The reversible process can be used to measure both kinetics o...

Dynamic atroposelective resolution of chiral salts derived from oily racemic nicotinamides and enantiopure dibenzoyltartaric acid (DBTA) was achieved by crystallization. The absolute structures of the axial chiral nicotinamides were determined by X-ray structural analysis. The chirality could be controlled by the selection of enantiopure DBTA as a chiral auxiliary. The axial chirality generated...

We have isolated ribulose-1,5-bisphosphate-carboxylase/oxygenase (RUBISCO) from the red algae Galdieria Sulphuraria. The protein crystallized in two different crystal forms, the I422 crystal form being obtained from high salt and the P21 crystal form being obtained from lower concentration of salt and PEG. We report here the crystallization, preliminary stages of structure determination and the...

We studied the crystallization of a globular protein, lysozyme, in the cubic phase of the lipid monoolein. The solubility of lysozyme in salt solution decreased by a factor of ∼ 4 when confined in cubic phase. Calculations and Monte Carlo simulations show that this can be explained by the confinement of lysozyme molecules to the narrow water cells in the cubic phase. We report a study of the cr...

Rhodopsin is a membrane protein from the G protein-coupled receptor family. Together with its ligand retinal, it forms the visual pigment responsible for night vision. In order to perform ultrafast dynamics studies, a time-resolved serial femtosecond crystallography method is required owing to the nonreversible activation of rhodopsin. In such an approach, microcrystals in suspension are delive...

Cosolvents are routinely used to modulate the (thermal) stability of proteins and, hence, their interactions with proteins have been studied intensely. However, less is known about their specific effects on protein-protein interactions, which we characterize in terms of the protein phase behavior. We analyze the phase behavior of lysozyme solutions in the presence of sodium chloride (NaCl), gua...

The structure and transport properties of the pure salt [N4]BF4 this located in contact with (110) surface a-Al2O3 were studied using a MD computer simulation order to reveal effect salt/oxide interface on salt. radial distribution functions ions their mean square displacements analyzed as function temperature during cooling It was found that all cases anions are more mobile than cations. molte...