Saponins are natural glycosides of steroid or triterpene which exhibited many different biological and pharmacological activities. Notably, saponins can also activate the mammalian immune system, which have led to significant interest in their potential as vaccine adjuvants. The most widely used saponin-based adjuvants are Quil A and its derivatives QS-21, isolated from the bark of Quillaja sap...

Saponins are a structurally diverse class of compounds occurring in many plant species, which are characterized by a skeleton derived of the 30-carbon precursor oxidosqualene to which glycosyl residues are attached. Traditionally, they are subdivided into triterpenoid and steroid glycosides, or into triterpenoid, spirostanol, and furostanol saponins. In this study, the structures of saponins ar...

Four new dammarane-type triterpene saponins named floranotoginsenosides A (1), B (2), C (3) and D (4), together with five known triterpene saponins, were isolated from the flowers of Panax notoginseng. Their structures were elucidated on the basis of spectral and chemical evidence.

soapnuts, generally grows in tropical and sub-tropical regions of Asia. It was reported that S. mukorossi possessed efficient natural surfactants and has served as commercial ingredient of shampoo and cosmetic cleansers. In addition, some pharmacological effects including anthelmintic, antidermatophytic, antiinflammatory, antimicrobial, antitussive, cytotoxic, haemolytic, and molluscicidal acti...

conclusions our findings suggest that the analgesic effect of hrcle may be mediated via both peripheral and central mechanisms. the presence of flavonoids might be responsible for the anti-nociceptive activity of this plant. results hrcle significantly inhibited the number of contractions induced by acetic acid in the writhing test at all doses, while anti-nociceptive activity was only shown at ...

Four new triterpenoid saponins, 3-O-([beta-D-glucopyranosyl-(1-->2)]-beta-D-galactopyranosyl)-11alpha-methoxy-23-hydroxylongispinogenin, 3-O-([beta-D-glucopyranosyl-(1-->2)]-beta-D-galactopyranosyl)-11alpha-methoxy-23,29-dihydroxylongispinogenin, 3-O-([beta-D-glucopyranosyl-(1-->2)]-beta-D-galactopyranosyl)-29-hydroxysaikogenin F and 3-O-([beta-D-glucopyranosyl-(1-->2)]-beta-D-galactopyranosyl)...

In soybean, triterpenoid saponin is one of the major secondary metabolites and is further classified into group A and DDMP saponins. Although they have known health benefits for humans and animals, acetylation of group A saponins causes bitterness and gives an astringent taste to soy products. Therefore, several studies are being conducted to eliminate acetylated group A saponins. Previous stud...

It is well known that spirostane-type saponins show various bioactivities. In our on-going program of screening these kinds of constituents from natural products, Yucca schidigera was found to be rich in them, and nine new spirostanol saponins, Yucca spirostanosides A₁ (1), A₂ (2), B₁ (3), B₂ (4), B₃ (5), C₁ (6), C₂ (7), C₃ (8), and D₁ (9), together with five known ones (10-14) were isolated fr...

Abstract Two new triterpenoid saponins, named giganteasaponin 5 and giganteasaponin 6, were isolated from the aboveground parts of Solidago gigantea and were defined to be 3-O-[ -D-Apio-D-furanosyl-(1 3)-D-glucopyranosyl-(1 3)-D-glucopyranosyl]-28-O { -L-rhamnopyranosyl-(1 3)-D-xylopyranosyl-(1 4)[ -D-xylopyranosyl-(1 3)]-L-rhamnopyranosyl-(1 2) [ -L-rhamnopyranosyl-(1 3)]-Dxylopyranosyl}-Bayog...

M. RENt MALINOW, WILLLAM E. CONNOR, PHYLLIS MCLAUGHLIN, CAROLYN STAFFORD, DON S. LIN, A. LYLE LIVINGSTON, GEORGE 0. KOHLER, and WILBUR P. MCNULTY, Oregon Regional Primate Research Center, Beaverton, Oregon 97006; University of Oregon Health Sciences Center, Portland, Oregon 97201; Western Regional Research Center, Science and Education Administration, United States Department of Agriculture, Be...