Obesity is one of the most important factors responsible for marked increase in both incidence and prevalence type 2 diabetes mellitus (T2DM) recent decades. Addressing lifestyle associated with progression to T2DM would present a potential rational early prevention strategy. The current evidence suggests that excessive energy intake mediated via dietary fat. Biochemical signals released respon...

BACKGROUND We found marked improvement of glucose tolerance and lower dietary energy intake in ischemic heart disease (IHD) patients after advice to follow a Paleolithic diet, as compared to a Mediterranean-like diet. We now report findings on subjective ratings of satiety at meals and data on the satiety hormone leptin and the soluble leptin receptor from the same study. METHODS Twenty-nine ...

BACKGROUND Maintenance of the botanical integrity of cereal kernels and the addition of acetic acid (as vinegar) in the product or meal has been shown to lower the postprandial blood glucose and insulin response and to increase satiety. However, the mechanism behind the benefits of acetic acid on blood glucose and satiety is not clear. We hypothesized that the gastric emptying rate could be inv...

Regulation of Satiety Quiescence: cyclic GMP, TGF beta, and the ASI Neuron By Thomas L. Gallagher A Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2013 Major Director: Young-Jai You, Ph.D. Assistant Professor, Department of Biochemistry and Molecular Biology ix The wo...

Cholecystokinin (CCK) signaling appears well conserved over evolution. In Drosophila, the CCK-like sulfakinins (DSKs) regulate aspects of gut function, satiety and food ingestion, hyperactivity and aggression, as well as escape-related locomotion and synaptic plasticity during neuromuscular junction development. Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechan...

background occurrence of hypersplenism in tb is very rare. we report a case of dtb with hypersplenism presentation. case presentation a 23year old man was admitted with complaints of fever, night sweats, anorexia, headache, shortness of breath, early satiety that had started 10 days ago. he had been well until 9 months ago, when early satiety developed for the first time. physical and ultrasono...