The poplar leaf rust fungus, Melampsora larici-populina has been established as a tree-microbe interaction model. Understanding the molecular mechanisms controlling infection by pathogens appears essential for durable management of tree plantations. In biotrophic plant-parasites, effectors are known to condition host cell colonization. Thus, investigation of candidate secreted effector proteins...

Filamentous fungi possess the extraordinary ability to digest complex biomasses and mineralize numerous xenobiotics, as consequence of their aptitude to sensing the environment and regulating their intra and extra cellular proteins, producing drastic changes in proteome and secretome composition. Recent advancement in proteomic technologies offers an exciting opportunity to reveal the fluctuati...

The potentialities to apply mesenchymal stem cells (MSCs) in regenerative medicine have been extensively studied over the last decades. In the cardiovascular disease (CVD) field, MSCs-based therapy is the subject of great expectations. Its therapeutic potential has been already shown in several preclinical models and both the safety and efficacy of MSCs-based therapy are being evaluated in huma...

Elective single embryo transfer is rapidly becoming the standard of care in assisted reproductive technology for patients under age 35 years with a good prognosis. Clinical pregnancy rates have become increasingly dependent on selection viable transfer, and diagnostic techniques facilitating this continue to develop. Current progress elucidating extracellular vesicle microRNA components embryon...

According to studies, the microbiome may contribute emergence and spread of breast cancer. E. coli is one Enterobacteriaceae family recently found be present as part tissue microbiota. In this study, we focused on effect secretome free cells MCF-7 metabolism. Liquid chromatography–mass spectrometry (LC-MS) metabolomics was used study its role in intra- extracellular metabolites. A comparison ma...

Senescence, a terminal cell proliferation arrest, can be triggered by oncogenes. Oncogene-induced senescence is classically considered a tumor defense barrier. However, several findings show that, under certain circumstances, senescent cells may favor tumor progression because of their secretory phenotype. Here, we show that the expression in different breast epithelial cell lines of p95HER2, a...

We have developed a computational strategy to identify the set of soluble proteins secreted into the extracellular environment of a cell. Within the protein sequences predominantly derived from the RIKEN representative transcript and protein set, we identified 2033 unique soluble proteins that are potentially secreted from the cell. These proteins contain a signal peptide required for entry int...