BACKGROUND Atrial septal defect (ASD) accounts for 10% of all congenital heart lesions and represent the third most congenital cardiac defect seen in adults. Atrial natriuretic peptide (ANP) is an important regulator of the sodium and volume homeostasis. This study was designed to investigate the changes in plasma ANP concentrations and three-dimensional echocardiography (3DE) measurements of c...

Atrial septal defect (ASD) closure is major therapy for patients with secundum ASD. Although surgical closure (SC) and transcatheter closure (TC) are usually performed in such patients, data on the long-term outcomes comparing TC and SC in adults are limited. Data on the participants of this cohort study were retrieved from Taiwan's National Health Insurance Research Database from 2004 to 2011....

Atrial septal defect closure is now routinely performed using a percutaneous approach under echocardiographic guidance. Centrally located, secundum defects are ideal for device closure but there is considerable morphological variation in size and location of the defects. A small proportion of atrial septal defects may have multiple fenestrations and these are often considered unsuitable for dev...

OBJECTIVE Noonan syndrome is a clinically homogeneous but genetically heterogeneous condition. Type 1 Noonan syndrome is defined by the presence of a mutation in the PTPN11 gene, which is found in approximately 40% of the cases. Phenotype descriptions and cardiac defects from cohorts with Noonan syndrome were delineated in the "pregenomic era." We report the heart defects and links to gene dysf...

Interestingly, previous studies shows that there are some regional differences regarding the extent and the time course of deformational changes. 2) The regional heterogeneity in RV wall thickness and curvature may explain some of the variance in RV regional deformation. In ASD patients, RV lateral longitudinal strain is higher and RV septal strain is similar (or slightly higher) compared with ...

This article presents a study on the use of three-dimensional transesophageal echocardiography (3D TEE) in evaluation atrial septal defects (ASD) adults. With 3D TEE, more accurate anatomical assessment septum is achieved, allowing precise measurement size, shape, and border characteristics ASD. In series 27 cases, showed strong correlation between measured parameters size closure device requir...

A 70-year-old-man was referred to our hospital for percutaneous closure of a secundum atrial septal defect (ASD). His transthoracic echocardiography (TTE) showed 2 left-to-right ASDs with a pulmonary/systemic flow ratio (Q p/Q s) of 1.89 and normal left ventricular function. Cardiac computed tomography (CT) using 320-detector row CT (Aquilion ONE VISION edition, Toshiba Medical Systems, Tokyo, ...

We describe clinical presentation in a male newborn baby who presented with thumb aplasia, forearm hypoplasia and secundum atrial septal defect (ASD II). The child has no other bone anomalies or facial dysmorphism. The ultrasound morphology of the brain is normal. He has patent ductus arteriosus, without abnormalities in the ECG record. Complete blood count (CBC) is normal. In the spectrum of h...

Echocardiography was used to evaluate mitral and tricuspid valve closure in patients 1 day to 20 years of age. When possible, simultaneous phonocardiograms were obtained. The difference in time between the Q wave of the electrocardiogram and mitral closure and between Q and tricuspid closure was designated the delta value (A). Four groups of patients were assessed: 1) normals (40), secundum atr...

INTRODUCTION Transcatheter closure has become the treatment of choice for secundum atrial septal defects (ASD II), but particularly in small children, there is concern regarding procedure-related complications. CASE DESCRIPTION We report on a 10-month-old infant, body weight of 6.4 kg, with a large ASD who was referred for failure to thrive and dyspnea on exertion. Echocardiography showed two...