Following previous studies on anthraquinone and acridine-based G-quadruplex ligands, here we present a study of similar aromatic cores, with the specific aim of increasing G-quadruplex binding and selectivity with respect to duplex DNA. Synthesized compounds include two and three-side chain xanthone and xanthene derivatives, as well as a dimeric "bridged" form. ESI and FRET measurements suggest...

This paper exploits how Bayesian learning of restricted Boltzmann machine (RBM) can discover more biologically-resembled early visual features. The study is mainly motivated by the sparsity and selectivity of visual neurons’ activations in V1 area. Most previous work of computational modeling emphasize selectivity and sparsity independently, which neglects the underlying connections between the...

We describe the design, fabrication, characterization, and modeling of an array of single transistor synapses. The single transistor synapses simultaneously perform long term weight storage, compute the product of the input and oating gate value, and update the weight value according to a hebbian or a backpropagation learning rule. The charge on the oating gate is decreased by hot electron inje...

In this article, modeling of ring resonator for the identification various cancer cells has been proposed. The model exhibits high Q factor and selectivity sensing cells. parameters design are optimized in sample based on its distinct refractive index. proposed device modeled by FDTD simulation method which confirms satisfactorily resonant wavelengths explored feasibility label-free cell with i...

the possibility of selective leaching process was investigated during molybdenite flue dust leaching to recover its rhenium content. the results show that addition of alcohols to water makes the medium less favorable for molybdenum transfer into aqueous phase. on the other hand, addition of small amounts of alcohols (5-15%) makes a noticeable separation of rhenium over molybdenum, but by increa...

11C-LY2795050 is a novel k-selective antagonist PET tracer. The in vitro binding affinities (Ki) of LY2795050 at the k-opioid (KOR) and m-opioid (MOR) receptors are 0.72 and 25.8 nM, respectively. Thus, the in vitro KOR/MOR binding selectivity is about 36:1. Our goal in this study was to determine the in vivo selectivity of this new KOR antagonist tracer in the monkey. Methods: To estimate the ...

Voltage-gated Ca(2+) channels (VGCC) play a key role in many physiological functions by their high selectivity for Ca(2+) over other divalent and monovalent cations in physiological situations. Divalent/monovalent selection is shared by all VGCC and is satisfactorily explained by the existence, within the pore, of a set of four conserved glutamate/aspartate residues (EEEE locus) coordinating Ca...

in a novel dual bed reactor fischer-tropsch synthesis was studied by using two diffrent cobalt catalysts. an alkali-promoted cobalt catalyst was used in the first bed of a fixed-bed reactor followed by a rutenuim promoted cobalt catalyst in the second bed. the activity, product selectivity and accelerated deactivation of the system were assessed and compared with a conventional single bed react...

an extensive study of fischer-tropsch synthesis (fts) on alumina-supported cobalt catalysts with different amounts of cobalt is reported. up to 40 wt % of cobalt, is added to the catalysts by impregnation method. the effect of the cobalt loading on the reducibility of the cobalt oxide species, dispersion of the cobalt, average clusters size, water-gas shift (wgs) activity and activity and selec...

Now there is tremendous interest in data warehousing and OLAP applications. OLAP applications typically view data as having multiple logical dimensions (e.g., product, location) with natural hierarchies de ned on each dimension, and analyze the behavior of various measure attributes (e.g., sales, volume) in terms of the dimensions. OLAP queries typically involve hierarchical selections on some ...