OBJECTIVE To evaluate selenium dietary intake and nutritional status of patients with phenylketonuria. METHODS The study prospectively evaluated 54 children with phenylketonuria, from 4 to10 years old. The study was performed before and after the use of a selenium-supplemented amino acid mixture. The second phase of the study was performed after, at least, 90 days of use of the supplementatio...

Pharmacokinetics Selenium levels in the body are largely dependent on the amount of the element in the diet. However, the form of selenium within the diet has an important influence on absorption. L-(+)selenomethionine is readily absorbed from the gastrointestinal tract and is significantly better absorbed and retained in the body than inorganic selenium in the form of selenite. L-(+)selenometh...

Two types of mechanisms are considered in this discussion of the interactions between compounds of selenium and those of cadmium or mercury: one based on a direct chemical reaction between compounds of these elements and the other based on metabolic changes induced by selenium administration and modifying the dose-effect relationship indirectly, without a reaction between selenium and the metal...

The common oxidation states of selenium found in the environment are selenides (-2), selenium (0), selenites (+4), and selenates (+6). The reduction of selenium oxyanions viz., selenate and selenite to insoluble Se which is less toxic form of selenium, has been reported in numerous bacteria and in some cases thought to be a detoxification mechanism [1]. Selenium reduction mechanisms in anaerobi...

In this issue, Stranges and colleagues (1) report findings from the Nutritional Prevention of Cancer (NPC) trial that show an increased risk for diabetes among participants randomly assigned to receive supplements with 200 g of selenium daily for 7.7 years compared with placebo. This effect was largely limited to participants in the top tertile of plasma selenium level at baseline ( 121.6 ng/mL...

introduction and aims: both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations. recent cancer registry data have shown very different rates of esophageal cancer (ec) and gastric cancer (gc) in four provinces of iran, namely ardabil, mazandaran, golestan, and kerman. the aim of this st...

two experiments were conducted to evaluate the different levels of selenium supplements on performance, blood metabolites and nutrient digestibility in mehraban male lambs. the first experiment consisted of 18 lambs, 4-5 months of age and 35.9±2.7 kg average in weight randomly allotted to 3 treatments. treatments were: 1) control diet (a diet without selenium, containing 0.06 ppm of selenium), ...

selenium is a metalloid that it is antioxidant characteristics is proved for humans, animals and plants. however, some plants are known as hyper accumulators for selenium and sometimes seems to be useful for growth of some plants. in this paper, we have studied the effect of different selenium concentrations on growth and morpho-physiological characteristics of spinach. seeds of spinach were ge...

introduction: there are limited reports about selenium status in major thalassemia patients. the aim of this study is evaluation of selenium status in patients with major thalassemia south east of iran with large sample size and wide range of age. this study compared selenium status with other sites of the world. methods: in this study 369 cases that had major thalassemia for more than 5 years ...

background: adequate serum level of zinc and selenium is required for normal metabolic performance and successful fertility. the present study was conducted to evaluate the association of serum zinc and selenium in early stage of gestation with the incidence of miscarriage in iranian women. materials and methods: one hundred two females were studied in three matched groups. group 1 consisted of...