Sepsis-induced disseminated intravascular coagulation (DIC) is a major cause of death in patients admitted to intensive care units. Endothelial injury with microparticle production is reported in the pathogenesis of sepsis. Endothelial microparticles (EMPs) present several cell-specific surface antigens with different bioactivities, for example, tissue factor (TF), thrombomodulin (TM), and endo...

The increase of multidrug-resistant bacteria - including Acinetobacter baumannii (A. baumannii) has been reported globally. aim this systematic review was to determine the risk factors A. infection, its resistance profile, reservoirs and mortality rates in Brazil. Data from over 3,000 patients were included. Results suggested that is widely transmitted Brazil endemic clones ST1, ST15, ST 25, ST...

To adapt the Sequential Organ Failure Assessment (SOFA) score to fit prehospital care needs; do that, SOFA was modified by replacing platelets and bilirubin, lactate, tested this (mSOFA) in its prognostic capacity assess mortality-risk at 2 days since first Emergency Medical Service (EMS) contact. Prospective, multicentric, EMS-delivery, ambulance-based, pragmatic cohort study of adults with ac...

AIMS we investigated the relationship between sublingual perfused capillary density (PCD) as a measure of tissue perfusion and outcome (i.e. occurrence of organ failure and mortality) in patients with cardiogenic shock from acute myocardial infarction. METHODS AND RESULTS we performed a prospective study in 68 patients. Using Sidestream Dark Field imaging, PCD was measured after hospital admi...

Critically ill cirrhotic patients with acute kidney injury (AKI) are associated with high mortality rates. The aims of this study were to develop a specific prognostic score for critically ill cirrhotic patients with AKI, the acute kidney injury - Chronic Liver Failure - Sequential Organ Failure- Assessment score (AKI-CLIF-SOFA) score. This study focused on 527 cirrhotic patients with AKI admit...