PURPOSE Epithelial ovarian carcinogenesis may occur de novo on the surface of ovarian mesothelial epithelial cells or from cells originating in other organs. Foreign Müllerian cell intrusion into the ovarian environment has been hypothesized to explain the latter scenario. In this study, MALDI MS profiling technology was used to provide molecular insights regarding these potentially different m...

BACKGROUND Mitotic arrest deficiency protein 2 (MAD2) is a key component of spindle assembly checkpoint function, which mediates cell apoptosis through microtubule kinetics. Aberrant expression of MAD2 is believed to be associated with the development of chromosome instability. MAD2 also has a signihicant role in cellular drug resistance to taxane chemotherapeutic agents. METHODS Expression o...

Although ovarian cancer is the most lethal gynecologic malignancy in women, little is known about how the cancer initiates and metastasizes. In the last decade, new evidence has challenged the dogma that the ovary is the main source of this cancer. The fallopian tube has been proposed instead as the primary origin of high-grade serous ovarian cancer, the subtype causing 70% of ovarian cancer de...

For the past several years, all women with epithelial ovarian cancer have been treated identically, whether in a clinical trial or off protocol. Over the past decade, we have come to appreciate the magnitude of the heterogeneity of ovarian cancer. The development of the binary grading system for serous carcinoma was a major advance, leading to separate clinical trials for patients with this sub...

Background: Understanding some part of the human body such as serous membrane, peritoneal cavity, lesser sac and proper mesentery is difficult for medical students. The objective of this study was to determine the effect of animal dissection on improving medical student knowledge and view related viscera and serous membrane anatomy. Methods: In YUMS in 2011, sixty eight medical students were ra...

Capillary instability of a two-layer liquid film lining rigid tube is studied computationally as model for plug formation and closure human airways. The consists serous layer, also called the periciliary at inner side mucus layer outer side. Together, they form airway surface wall surrounding an air core. Liquid occurs due to Plateau–Rayleigh when thickness exceeds critical value. Numerical sim...

OBJECTIVE Transcriptional profiling of epithelial ovarian cancer has revealed molecular subtypes correlating to biological and clinical features. We aimed to determine gene expression differences between malignant, benign and borderline serous ovarian tumors, and investigate similarities with the well-established intrinsic molecular subtypes of breast cancer. METHODS Global gene expression pr...

We report a case of bimatoprost induced serous macular detachment and choroidal folds following uneventful cataract surgery. A 66-year-old male using topical bimatoprost in both eyes for open angle glaucoma underwent uneventful cataract surgery in the right eye. Postoperatively, he was restarted on topical bimatoprost and antibiotic-steroids combination drops. One week after surgery, he present...

BACKGROUND Primary serous-papillary peritoneal carcinoma is able to spread to the retroperitoneal lymph nodes, but there is no evidence of the pattern of lymphatic metastasis. Because of the fact that this tumor entity is indistinguishable histologically from primary serous-papillary ovarian carcinoma, its taxonomic position has thus far remained unclear. MATERIALS AND METHODS The Medline dat...

In the United States, ovarian carcinoma remains the most deadly gynecologic malignancy, and approximately 14,000 deaths are projected from the disease in 2017 [1]. Ovarian carcinoma comprises various histologic subtypes based on the cell of origin, with serous carcinoma being the most common subtype. Serous ovarian carcinomas are commonly grouped into 2 types based on histologic characteristics...