Some years ago, we found that Axial organ (AO) cells exerted an induced and spontaneous cytotoxicity against SP2 MBL2 mouse tumoral cells. Recently, discovered a sea star Igkappa gene with immune properties. This was first, inserted in CMV (cytomegalovirus) finally plasmid called « young » plasmid. In the present experiment IGKappa cloned HeK human to produce specific protein. The induced« prot...

The manner by which genotype and environment affect complex phenotypes is one of the fundamental questions in biology. In this study, we quantified the transcriptome--a subset of the metabolome--and, using targeted proteomics, quantified a subset of the liver proteome from 40 strains of the BXD mouse genetic reference population on two diverse diets. We discovered dozens of transcript, protein,...

Based on the HVZ theorem and dilation analyticity of the pseudorelativistic no-pair Jansen-Hess operator, it is shown that for subcritical potential strength (Z ≤ 90) the singular continuous spectrum is absent. The bound is slightly higher (Z ≤ 102) for the Brown-Ravenhall operator whose eigenvalues λ are, by the virial theorem, confined to λ < 2m if Z ≤ 50.

Cone Dystrophy with Supernormal Rod Response (CDSRR) is a rare autosomal recessive disorder leading to severe visual impairment in humans, but little known about its unique pathophysiology. We have previously shown that CDSRR caused by mutations the KCNV2 (Potassium Voltage-Gated Channel Modifier Subfamily V Member 2) gene encoding Kv8.2 subunit, modulatory subunit of voltage-gated potassium (K...

Replication Protein A (RPA) is a single stranded DNA-binding protein involved in DNA metabolic activities such as replication, repair, and recombination. RPA-Interacting Protein alpha (RIPalpha) was originally identified as a nuclear transporter of RPA in Xenopus. The human RIPalpha gene encodes several splice isoforms, of which hRIPalpha and hRIPbeta are the major translation products in vivo....

Plasmodium falciparum, which causes the most lethal form of human malaria, replicates in the host liver during the initial stage of infection. However, in vivo malaria liver-stage (LS) studies in humans are virtually impossible, and in vitro models of LS development do not reconstitute relevant parasite growth conditions. To overcome these obstacles, we have adopted a robust mouse model for the...

Background Beta cell dysfunction and death are critical steps in the development of both type 1 2 diabetes (T1D T2D), but underlying mechanisms incompletely understood. Activation essential tumor suppressor transcription factor P53 was linked to beta vitro has been reported several mouse models cells humans with T2D. Therefore, we investigated specific role dysfunction, vivo.

OBJECTIVE To examine CD11c, a beta(2)-integrin, on adipose tissue (AT) leukocytes and blood monocytes and its role in diet-induced obesity. METHODS AND RESULTS High-fat diet-induced obese C57BL/6 mice, CD11c-deficient mice, and obese humans were studied. CD11c, leukocytes, and chemokines/cytokines were examined in AT and/or blood by flow cytometry, RNase protection assay, quantitative polymer...

PURPOSE The gene expression profile of human corneal endothelium (CE) was established with the gene signature system. A novel gene, GS3582, was abundantly transcribed in the CE compared with other tissues according to a human gene expression database. This protein was designated corneal endothelium-specific protein (CESP)-1. The tissue distribution and subcellular localization of CESP-1 was ass...

Experimental animal models play an essential role in the study of pathogenic mechanisms and development novel therapies for diseases. Many disease are developed by introducing genetic factors environmental onset through drug administration, surgery, or modification that results phenotypes. In addition, higher animals such as non-human primates useful investigating diseases whose phenotypes cann...