Clinical assessment of kidney function is central to the practice of medicine. Glomerular filtration rate (GFR) is widely accepted as the best index of kidney function in health and disease and accurate values are required for optimal decisionmaking in many clinical settings. GFR is generally not measured in clinical practice, but is estimated from the serum level of an endogenous filtration ma...

BACKGROUND Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correction factors in the originally developed creatinine-based GFR estimation equations for populations around the world. Existing equations have not been validated in the vegetarian ...

BACKGROUND Cystatin C is a new interesting marker of glomerular filtration rate (GFR). However, data regarding its biological variance are scarce and conflicting. The ability of cystatin C to longitudinally follow renal function in patients therefore remains questionable. METHODS 12 healthy subjects (6 men and 6 women) were included in the final statistical analysis. Serum creatinine, plasma ...

BACKGROUND Estimating equations are recommended by clinical guidelines as the preferred method for assessment of glomerular filtration rate (GFR). The aim of the study was to compare population-based prevalence estimates of decreased kidney function in Germany defined by an estimated GFR (eGFR) <60 ml/min/1.73m2 using different equations. METHODS The study included 7001 participants of the Ge...

The use of outpatient laboratory databases to identify people with a low GFR may be part of an effective strategy to increase their use of treatments to prevent kidney failure. All renal function data from 17 independent outpatient laboratories in Eastern Ontario were combined to determine the proportion of adults with at least one serum creatinine measurement during a 1-yr period. The detectio...

Kidney disease in HIV-infected persons manifests in a variety of ways, including acute kidney injury (AKI), HIV-associated kidney disease, comorbid chronic kidney disease (CKD), and treatment-related kidney toxicity. The burden of CKD and end-stage renal disease (ESRD) remains high in the HIVinfected population. There are several important caveats to consider when diagnosing and managing kidney...

Chronic kidney disease (CKD) is an important social health problem characterized by a decrease in the kidney glomerular filtration rate (GFR). In this study, we analyzed genome-wide association studies for kidney disease-related traits using data from a Korean adult health screening cohort comprising 7,064 participants. Kidney disease-related traits analyzed include blood urea nitrogen (BUN), s...

INTRODUCTION Creatinine is released into the blood following non-enzymatic hydrolysis of creatine in skeletal muscle, and excreted into urine depending on glomerular filtration. The serum creatinine concentration is widely used as a marker of glomerular function because it increases in patients with decreased glomerular filtration rate (GFR). Although GFR is costly to measure, an estimated GFR ...

BACKGROUND AND OBJECTIVES Creatinine-based estimates of GFR suggest an evolving epidemic of chronic kidney disease (CKD) in U.S. adults that is inadequately explained by conventional, modifiable risk factors. Cystatin C has recently emerged as a promising measure of GFR. To enable further insights into the evolution of CKD in the U.S. population, this study aimed to examine cystatin C levels in...

There is ominous growth in chronic kidney disease among the US population, primarily related to type 2 diabetes (1 ). The current number of patients on dialysis ( 300 000) is growing steadily as the prevalence of endstage kidney disease grows geometrically with a doubling time of 10 years. The epidemic growth in diabetes, the leading cause of chronic kidney disease, portends continuation of thi...