BACKGROUND Amlodipine and hydrochlorothiazide (HCTZ) are commonly prescribed in Nigeria either as a monotherapy or in combination with other drugs. The present study was designed to investigate the antihypertensive efficacy of monotherapy with amlodipine or HCTZ and their effects on electrolyte profile in patients with mild to moderate hypertension. METHODS A single-blind randomized clinical ...

OBJECTIVE To determine the frequency of hyponatraemia and hypokalaemia in malnourished children with acute diarrhoea. METHODS This cross-sectional study was carried out at the Military Hospital, Rawalpindi, Pakistan, from September 2013 to March 2014, and comprised acute diarrhoea patients whose ages ranged from six months to five years. Blood samples for serum sodium and potassium were exami...

BACKGROUND Channelopathies, defined as diseases that are caused by mutations in genes encoding ion channels, are associated with a wide variety of symptoms and have been documented extensively over the past decade. In contrast, despite the important role of chloride in serum, textbooks in general do not allocate chapters exclusively on hypochloremia or hyperchloremia and information on chloride...

Aim: To evaluate the electrolyte imbalance associated with the use of two important Aminoglycosides (Amikacin and Gentamicin) in experimental rabbit model. Gentamicin and Amikacin 5mg/kg/day and 15mg/kg/day respectively were continued for seven days in two different groups i.e., Group G (Gentamicin treated group) and Group A (Amikacin treated group) along with Control Group (Group C) being on s...

Hadjikoutis and Wiles draw attention to a number of circumstances in which the serum chloride and bicarbonate can be misleading. They do not mention that they will also be misleading if they are measured when hypercapnia is increasing or decreasing. An exacerbation of hypercapnia will take 4 – 6 days to raise the serum bicarbonate and lower the serum chloride to new steady levels. 1 How long it...

INTRODUCTION: Hypothyroidism is a clinical condition resulting from inadequate synthesis of the thyroid hormones. Thyroid hormone has an influence on renal hemodynamics, glomerular filtration, as well renin angiotensin aldosterone system and electrolyte handling. The aim present study was to find out serum concentration electrolytes sodium potassium in hypothyroid patients attending tertiary ca...